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β-Anhydroicaritin

Catalog No. T6S2140 CAS 38226-86-7

Synonyms: Beta-Anhydroicaritin, Anhydroicaritin

1. Anhydroicaritin exhibits immunosuppressive effect on the mouse macrophages stimulated by LPS. 2. Anhydroicaritin phytosomes can inhibit enhanced bone turnover induced by ovariectomy, improve BMD the biomechanical properties of vertebrae, without any stimulation on uterus. 3. Anhydroicaritin possesses significant protective effects on the zymosan-induced peritonitis mice, which might be associated with the regulation of Ca(2+); influx in macrophages and iNOS expression.

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β-Anhydroicaritin, CAS 38226-86-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 59.00
10 mg	In stock	$ 95.00
25 mg	In stock	$ 168.00
50 mg	In stock	$ 252.00
100 mg	In stock	$ 378.00
500 mg	In stock	$ 997.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 96.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Beta-Anhydroicaritin, Anhydroicaritin
Molecular Weight	368.385
Formula	C21H20O6
CAS No.	38226-86-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2020 2. Wang Z, Xu G, Wang H, et al. Icariside Ⅱ Contributes to Epimedii folium-Induced Hepatotoxicity Through Enhancing NLRP3 Inflammasome Activation[J]. Epimedii folium. 2019. 3. Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2020 4. Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity[J]. Cell Communication and Signaling. 2021, 19(1): 1-14.

Citations

1. Wang Z, Xu G, Wang H, et al. Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation. Acta Pharmaceutica Sinica B. 2020 2. Gao Y, Xu G, Ma L, et al. Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling. 2021 Feb 11;19(1):13. doi: 10.1186/s12964-020-00647-1. 3. Gao Y, Xu G, Ma L, et al. Icarisid I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity. Cell Communication and Signaling. 2020

Related compound libraries

This product is contained In the following compound libraries：

Anti-Fibrosis Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Inhibitor Library Traditional Chinese Medicine Monomer Library RO5 Drug-like Natural Product Library Polyphenolic Natural Product Library Chinese Pharmacopoeia Natural Product Library Flavonoid Natural Product Library Immuno-Oncology Compound Library Angiogenesis related Compound Library

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Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

β-Anhydroicaritin 38226-86-7 Apoptosis Immunology/Inflammation Others Proteases/Proteasome MMP TNF Interleukin βAnhydroicaritin TNFR Beta-Anhydroicaritin β Anhydroicaritin Interleukin Related Matrix metalloproteinases Anhydroicaritin inhibit Inhibitor TNF Receptor Tumor Necrosis Factor Receptor inhibitor

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