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PPADS tetrasodium

Catalog No. T16564 CAS 192575-19-2

PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma inhibits P2X1, P2X-2, P2X-3, and P2X- 5. 5.

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PPADS tetrasodium, CAS 192575-19-2

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2 mg	In stock	$ 95.00

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Chemical Properties

Storage & Solubility Information

Description	PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma inhibits P2X1, P2X-2, P2X-3, and P2X- 5. 5.
Targets&IC50	P2XRs:1-3 μM, P2X4 (human):30 μM
In vitro	In a time- and concentration-dependent manner, PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV)[2]. PPADS tetrasodiuma is effective at other native and recombinant P2XRs. Sensitivity to PPADS tetrasodiuma at human P2XRs depends on the subtype and is highest at the hP2X1, -2, -3, -5, and -7Rs with an IC50 of ~1-3 μM and ~30 μM for the hP2X4R[3].
In vivo	In mesangial proliferative glomerulonephritis, PPADS tetrasodiuma (15-60 mg/100g body weight (BW); i.p.; every 12 hours for 8 days) inhibits the proliferation of glomerular mesangial cells (MC) without altering the proliferation of non-MC in vivo[4].

Molecular Weight	599.3
Formula	C14H10N3Na4O12PS2
CAS No.	192575-19-2

Storage

keep away from moisture,store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 40 mg/mL (66.74 mM), Sonication is recommended.

References and Literature

1. Flores-Soto E, et al. PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na⁺/Ca²⁺ exchanger in guinea pig airway smooth muscle. Eur J Pharmacol. 2012 Jan 15;674(2-3):439-44. 2. Rost S, et al. P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangialproliferative glomerulonephritis. Kidney Int. 2002 Nov;62(5):1659-71. 3. Einfluss von ATP und seinen Derivaten auf die Aktivierung von Monozyten. 4. Huo H, et al. Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region. J Biol Chem. 2018 Aug 17;293(33):12820-12831.

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Keywords

PPADS tetrasodium 192575-19-2 Membrane transporter/Ion channel Neuroscience P2X Receptor Na+/Ca2+ Exchanger PPADS inhibitor inhibit

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