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AZT

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    14
    TargetMol | Activity
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    TargetMol | natural
Zidovudine
T141630516-87-1
Zidovudine (ZDV) is a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zidovudine inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. This agent also decreases levels of available pyrimidines.
  • $44
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TargetMol | Citations Cited
ddC-AZT dimer
T31231121892-89-5
ddC-AZT dimer is a biochemical.
  • $1,520
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Azt-pmap
T14488142629-81-0
AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1]. As a nucleoside reverse transcriptase inhibitor (NRTI), AZT-PMPA targets HIV infection effectively[2].
  • $1,820
8-10 weeks
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AZT triphosphate
TNU122992586-35-1
AZT triphosphate is a Nucleoside Triphosphate.
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7-10 days
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AZT triphosphate tetraammonium
T73837106060-92-8
AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV . AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV . AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway [1] [2] [3] .
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AZT triphosphate TEA
T36490
AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1]. [1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.
  • $601
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Aztreonam
T102978110-38-0
Aztreonam (SQ-26,776), a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum, possesses bactericidal activity.
  • $35
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Phosphazide
T34031124930-59-2
Phosphazide is a zidovudine prodrug.
  • $1,820
8-10 weeks
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Kamuvudine-8
T85346 In house
Kamuvudine-8 (K8) is a zidovudine (AZT) derivative that can be used to study diabetic macular edema.
  • $189
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Azthreonam monosodium salt
T3028080581-85-7
Azthreonam monosodium salt is a synthetic monobactam specifically active against aerobic gram-negative bacteria.
  • $1,520
6-8 weeks
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Aztreonam lysine
T25136827611-49-4
Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF).
  • $1,520
1-2 weeks
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Azthreonam dipotassium salt
T3028180581-95-9
Azthreonam dipotassium salt is a synthetic monobactam which targets gram-negative bacteria.
  • $1,520
6-8 weeks
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Raluridine
T19689119644-22-3
Raluridine is a RNA-directed DNA polymerase inhibitor potentially for the treatment of HIV infection. 935U83 inhibited virus growth with an average 50% inhibitory concentration (IC50: 1.8 microM) corresponding IC50s were 0.10 microM for FLT (3'-deoxy-3'-f
  • $1,970
8-10 weeks
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R-82913
T28494126347-69-1
R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 of 0.15 microM. R82913 was 20-fold
  • $1,670
6-8 weeks
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