well-tolerated — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0343	Nimodipine	BAY-e 9736	Glucocorticoid Receptor , AhR , Calcium Channel , Autophagy
	Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.		Glucocorticoid Receptor , AhR , Calcium Channel , Autophagy
T15549	Icosabutate		Others
	Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persist...		Others
T0217	Levodropropizine	(S)-(-)-Dropropizine,DF-526	5-HT Receptor , Histamine Receptor
	Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug.		5-HT Receptor , Histamine Receptor
T9186	Ervogastat	PF-06865571	Transferase
	Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).		Transferase
T67805	Oxepinac
	oxepinac is an effective and well-tolerated compound for the treatment of painful osteoarthritis. oxepinac has no teratogenic effect on mouse and rabbit fetuses in animal experiments.
T22349	JNJ-38158471	CS-2660	VEGFR , c-RET , c-Kit
	JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM.		VEGFR , c-RET , c-Kit
T1458	Epalrestat	ONO2235	Reductase
	Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particul...		Reductase
T14922	Cefodizime		Antibacterial , Antibiotic
	Cefodizime is a new cephalosporin antibiotic with a wide range of biological activities.Cefodizime is non-toxic to the kidneys and is well tolerated with immunomodulatory activity.Cefodizime has antimicrobial activity an...		Antibacterial , Antibiotic
T10896L	CSRM617 hydrochloride	CSRM617 hydrochloride(787504-88-5 Free base)	Apoptosis , Others , Androgen Receptor
	CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 ( OC2, a master regulator of androgen receptor) with a K d of 7.43 uM in SPR assays, directly binds to OC2-HOX domain. CSR...		Apoptosis , Others , Androgen Receptor
T3334	Velpatasvir	GS-5816	HCV Protease , SARS-CoV
	Velpatasvir (GS-5816), also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. GS-5816 has demonstrated pan-genotypic activity and a high barrier to resistance in HCV replicon assays. GS-5816 d...		HCV Protease , SARS-CoV
T4306	CCG-203971	CCG203971	Rho , Ras
	CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This compound also inhibits PC-3 cell migration (IC50: 4.2 μM),...		Rho , Ras
T37535	Camrelizumab	SHR-1210
	Camrelizumab (SHR-1210) is a human IgG4-κ monoclonal antibody with high affinity and directed against PD-1.Camrelizumab binds PD-1 with a binding affinity of up to 3 nM and is inhibitory to PD-1/PD-L1 with an IC50 of 0.7...
T4615	Balsalazide sodium hydrate	Balsalazide disodium dihydrate,Balsalazide disodium salt dihydrate,Balsalazide disodium	STAT , Interleukin
	Balsalazide sodium hydrate (Balsalazide disodium) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide sodium hydrate is a new 5-aminosalicylic acid (5-ASA) containing prodrug....		STAT , Interleukin
T0866	Propafenone	Rythmol,Propafenonum	Potassium Channel , MRP , Sodium Channel
	Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....		Potassium Channel , MRP , Sodium Channel
T33815	ORC-13661 HCl	ORC 13661,BPN13661,ORC13661,ORC-13661,BPN 13661,BPN-13661
	Orc-13661 (BNP-13661) is a potent and well-tolerated oral active protective agent for the prevention of aminogrogycoside-induced hearing loss.
T24809	SMU-B	SMU B
	SMU-B is a well-tolerated c-Met/ALK dual inhibitor.
T24699	R1498	R-1498,R 1498
	R1498 is an inhibitor of cyclin-dependent kinase 2. It also acts by targeting angiogenesis and mitosis pathways. It is well-tolerated and orally active for hepatocellular carcinoma and gastric cancer treatment.
T11013	Dextrorotation nimorazole phosphate ester		Others
	Dextrorotation nimorazole phosphate ester is an anti-anaerobic and anti-parasitic agent. D-morpholine ornidazole organic phosphate is a newly developed, highly efficient, well-tolerated fourth-generation nitroimidazole d...		Others
T10870	CP-547632 hydrochloride		FGFR
	CP-547632 hydrochloride is a well-tolerated and orally-bioavailable inhibitor of the VEGFR-2 and basic FGF kinases (IC50s: 11 nM and 9 nM) with antitumor efficacy.		FGFR
T15365	G-744		BTK
	G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is well-tolerated, metabolically stable. It also has an efficacious to treat arthritis.		BTK