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Nimodipine

Catalog No. T0343 CAS 66085-59-4

Synonyms: BAY-e 9736

Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.

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Nimodipine, CAS 66085-59-4

Pack Size	Availability	Price/USD
50 mg	In stock	$ 40.00
100 mg	In stock	$ 48.00
500 mg	In stock	$ 72.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.71%

Purity: 99.64%

Purity: 99.56%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
In vivo	Nimodipine (5-20 mg/kg, SC) suppresses in a dose-related manner self-administration both of cocaine and morphine contingent upon a nose-poke response. Nimodipine (10 mg/kg, SC), an L-type dihydropyridine Ca2+ channel antagonist, exhibits to completely block the establishment of conditioning of cocaine's effects, but only partially blocks sensitization to cocaine.

Synonyms	BAY-e 9736
Molecular Weight	418.44
Formula	C21H26N2O7
CAS No.	66085-59-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 4.2 mg/mL (10 mM)

DMSO: 41.8 mg/mL (100 mM)

References and Literature

1. Moyer JR Jr, et al. J Neurophysiol,1992, 68(6), 2100-2109. 2. Moyer JR Jr, et al. Hippocampus,1994, 4(1), 11-17. 3. Bobbin RP, et al. Hear Res,1990, 46(3), 277-287. 4. Reimer AR, et al. Psychopharmacology (Berl),1994, 113(3-4), 404-410. 5. Kuzmin A, et al. Pharmacol Biochem Behav,1992, 41(3), 497-500.

Citations

1. Zhu H, Liu X, Wang X, et al.Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways.European Journal of Pharmacology.2023: 176038.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Ion Channel Inhibitor Library Endocrinology-Hormone Compound Library Neuronal Signaling Compound Library Clinical Compound Library Anti-Aging Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nimodipine 66085-59-4 Autophagy Endocrinology/Hormones Immunology/Inflammation Membrane transporter/Ion channel Metabolism Glucocorticoid Receptor AhR Calcium Channel cerebrovascular dihydropyridine light-sensitive Ca2+ channels calcium well-tolerated Inhibitor BAY-e 9736 orally inhibit Ca channels inhibitor

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