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CCG-203971

Catalog No. T4306 CAS 1443437-74-8

Synonyms: CCG203971

CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This compound also inhibits PC-3 cell migration (IC50: 4.2 μM), as determined by a scratch wound assay. CCG-203971 causes no cytotoxicity when evaluated by the WST-1 assay. It is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CCG-203971, CAS 1443437-74-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 31.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 97.00
50 mg	In stock	$ 169.00
100 mg	In stock	$ 263.00
500 mg	In stock	$ 643.00
1 mL * 10 mM (in DMSO)	In stock	$ 34.00

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Purity: 99.35%

Purity: 98.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

SRE.L:0.64 μM

Synonyms	CCG203971
Molecular Weight	408.88
Formula	C23H21ClN2O3
CAS No.	1443437-74-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 73 mg/mL(178.5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Haak AJ, et al. Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. 2. Johnson LA, et al. Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts. Inflamm Bowel Dis. 2014 Jan;20(1):154-65.

Related compound libraries

This product is contained In the following compound libraries：

Related Products

Related compounds with same targets

CCG-257081 Y16 acetate(429653-73-6 free base) Rac1 Inhibitor F56, control peptide acetate Digeranyl bisphosphonate Rhosin SAR407899 CCG-100602 Azathioprine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CCG-203971 1443437-74-8 Cell Cycle/Checkpoint GPCR/G Protein MAPK Rho Ras Inhibitor SRF CCG 203971 MKL1 CCG203971 inhibit MRTF anti-metastasis PC-3 migration inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.