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Epalrestat

Catalog No. T1458 CAS 82159-09-9

Synonyms: ONO2235

Epalrestat, an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy and good glycemic control.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Epalrestat, CAS 82159-09-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 46.00
25 mg	In stock	$ 67.00
50 mg	In stock	$ 89.00
100 mg	In stock	$ 144.00
200 mg	In stock	$ 218.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

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Purity: 99.2%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	ONO2235
Molecular Weight	319.39
Formula	C15H13NO3S2
CAS No.	82159-09-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 9 mg/mL (28.18 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ramirez MA, et al. PharmacOthersapy. 2008 May; 28(5):646-55.

Citations

1. Xiao P, Hu Z, Lang J, et al.Mannose metabolism normalizes gut homeostasis by blocking the TNF-α-mediated proinflammatory circuit.Cellular & Molecular Immunology.2022: 1-12.

Related compound libraries

This product is contained In the following compound libraries：

Endocrinology-Hormone Compound Library Approved Drug Library Orally Active Compound Library Anti-Metabolism Disease Compound Library Anti-Diabetic Compound Library Pediatric Drug Library Bioactive Compound Library Bioactive Compounds Library Max NMPA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Epalrestat 82159-09-9 Endocrinology/Hormones Metabolism Reductase inhibit Aldose Reductase Inhibitor ONO 2235 ONO-2235 ONO2235 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.