transplantation — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T37596	Terevalefim		c-Met/HGFR
	Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.		c-Met/HGFR
T12783	RWJ 50271		Integrin
	RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 cells).		Integrin
T2161	Cardiogenol C		Wnt/beta-catenin
	Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.		Wnt/beta-catenin
T8005	Cardiogenol C hydrochloride	Cardiogenol C HCl,Cardiogenol C	Wnt/beta-catenin
	Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).		Wnt/beta-catenin
T10009	JAK3-IN-7		JAK
	JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50<0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after organ transplantation, autoimmune disorders, allergic diseases, ...		JAK
T31795	FK-330	LS-192510,FR-260330,FK330,FK 330	NOS
	FK-330 (FR-260330) is a novel orally active inducible nitric oxide synthase inhibitor with potential anticancer and antitumor activity that prevents ischemia and reperfusion injury in rat liver transplantation.		NOS
TN4661	Nodosin		IL Receptor , Autophagy
	Nodosin has anti-inflammatory function of Nodosin via inhibition of IL-2. Nodosin perfusion provides a potential protective effect through inducing HO-1 expression to attenuate ischemia/reperfusion injury in liver transp...		IL Receptor , Autophagy
T6459	Cyclosporine		Phosphatase
	Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation.		Phosphatase
T73698	Basiliximab	CHI 621	Interleukin
	Basiliximab (CHI 621) is a chimeric mouse/human IgG1 monoclonal recombinant antibody against the interleukin-2 receptor. Basiliximab has good immunosuppressive activity and can be used in the study of kidney transplantat...		Interleukin
T68879	FK-330 dihydrate	FR-260330 dihydrate	NO Synthase
	FK-330 dihydrate（FR-260330 dihydrate） is a novel orally active inducible nitric oxide synthase inhibitor with potential anticancer and antitumor activity to prevent ischemia and reperfusion injury in rat liver transplant...		NO Synthase
T4238	Glycocyamine	2-Guanidinoacetic acid,Guanidoacetic acid	Others , Endogenous Metabolite
	Glycocyamine (2-Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird. Glycocyamine is an important marker for renal failure, kidney...		Others , Endogenous Metabolite
T20578	Maclurin	Fustic extract,Morintannic acid,NSC 83240	Free radical scavengers , Reactive Oxygen Species
	Maclurin (NSC-83240) is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and can be used in studies about the prevention of ...		Free radical scavengers , Reactive Oxygen Species
T76870	Narsoplimab	OMS 721	SARS-CoV
	Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody, a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 and prevents lectin pathway ac...		SARS-CoV
T76794	Ulocuplumab	BMS 936564,MDX 1338	Apoptosis , CXCR
	Ulocuplumab (BMS-936564) is a fully human anti-CXCR4 IgG4 antibody.Ulocplumab exhibits antitumor activity in acute myeloid leukemia (AML), non-Hodgkin's lymphoma (NHL), and multiple myeloma transplantation models.Ulocplu...		Apoptosis , CXCR
TJS1779	Protosappanin A	PTA	NADPH-oxidase , IL Receptor , IκB/IKK , TNF , NF-κB , TLR , ROS , COX , HIV Protease , JAK , NO Synthase , STAT
	Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammation signal pathway; it exerts anti-neuroinflammatory ...
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
T15238	Epoprostenol sodium	Prostaglandin I2 sodium salt,Prostacyclin sodium salt,Flolan	Others
	Epoprostenol sodium is a potent inhibitor of platelet aggregation used in pulmonary hypertension and transplantation.		Others
T36944	Ara-G		Nucleoside Antimetabolite/Analog
	Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate...		Nucleoside Antimetabolite/Analog
T76951	Zampilimab
	Zampilimab (UCB-7858), a monoclonal antibody targeting transglutaminase 2 (TG2), exhibits potential applications in renal transplantation [1] [2].
T19848	Cyclosporin B	7-L-Alanine-cyclosporin A,Antibiotic S 7481F2
	Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B i...