squamous — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T26889	Borofalan(10B)	L-4-Boronophenylalanine	Others
	Borofalan(10B) (L-4-Boronophenylalanine) echibits antineoplastic effects. Borofalan can be used in studies on recurrent or locally advanced head and neck cancer.		Others
T2786	Oxysophocarpine		Prostaglandin Receptor
	Oxysophocarpine is extracted from Sophra flavescens Ait.		Prostaglandin Receptor
T12695	RBN-2397		PARP
	RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.		PARP
T15771	Lobaplatin	D-19466	DNA Alkylation
	Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent which shows activity for a variety of tumour types and is a ...		DNA Alkylation
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T0314	Hexylresorcinol	4-Hexylresorcinol	Apoptosis , Tyrosinase , Antibacterial , Parasite
	Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.		Apoptosis , Tyrosinase , Antibacterial , Parasite
T4570	Pipobroman	Vercyte,A-8103,Amedel	Others , DNA Alkylator/Crosslinker
	Pipobroman (Vercyte) is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET). Pipobroman allows, wit...		Others , DNA Alkylator/Crosslinker
T6485	Embelin	NSC 91874,Emberine,Embelic acid	Apoptosis , NF-κB , Lipoxygenase , IAP , Prostaglandin Receptor , Autophagy
	Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T0134	Imiquimod	R 837,S-26308	SARS-CoV , TLR , Autophagy , HSV
	Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.		SARS-CoV , TLR , Autophagy , HSV
T17035	Temoporfin		Others
	Temoporfin used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck.		Others
T14903	CCT129957		Calcium Channel , Phospholipase
	CCT129957 is a novel and potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of about 3 μM and a GC50 of 15 μM.CCT129957 exhibits anticancer activity and inhibits Ca2+ release in squamous cells.		Calcium Channel , Phospholipase
T76717	Serplulimab	HLX 10	COX
	Serplulimab (HLX 10) is a humanized monoclonal anti-antibody to PD-1. Serplulimab has antitumor activity and can be used in small cell lung cancer and esophageal squamous cell carcinoma.		COX
T38387	Compound C108		GTPase
	Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.		GTPase
T6136	Canertinib	PD-183805,CI-1033	EGFR
	Canertinib (CI-1033) is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo. Canertinib treatment significantly affects tumour metabolism, proliferation and hyp...		EGFR
T2618	LGK974	LGK 974,LGK-974,NVP-LGK974,WNT974	Porcupine
	LGK974 (NVP-LGK974) is an effective and selective PORCN inhibitor and inhibits Wnt signaling (IC50: 0.4 nM) in TM3 cells. It has been used in trials studying the treatment of Metastatic Colorectal Cancer and Squamous Cel...		Porcupine
T67786	ABI-1968 PM
	ABI-1968 PM is a derivative of ABI-1968, an apoptosis-stimulating agent and an inhibitor of viral replication.ABI-1968 can be used to study cervical intraepithelial neoplasia, papillomavirus infection, and squamous intra...
T77423	Lirilumab	ONO-4483,IPH2102	Virus Protease
	Lirilumab (IPH2102) is an antibody against the lethal immunoglobulin-like receptor antibody KIR2D with antitumor activity that enhances the anti-HPV + cervical cancer activity of natural killer cells through VAV1-depende...		Virus Protease
T76750	Cemiplimab	REGN-2810,SAR-439684	Others
	Cemiplimab (Anti-Human PD-1) is a human monoclonal antibody against programmed cell death receptor 1 (PD-1) and a checkpoint inhibitor that blocks PD-1/PD-L1 mediated T-cell inhibition and can be used in metastatic cance...		Others
T76691	Monalizumab		IFNAR , Chk
	Monalizumab is a novel immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab is a humanized monoclonal antibody against NKG2A that induces IFN-γ production, thereby activating natur...		IFNAR , Chk
T9636	Dalpiciclib	SHR-6390	CDK
	Dalpiciclib (SHR-6390) is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpiciclib exerts potent antitumor activity in esophag...		CDK