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RBN-2397

Catalog No. T12695 CAS 2381037-82-5

RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.

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RBN-2397, CAS 2381037-82-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 168.00
5 mg	In stock	$ 416.00
10 mg	In stock	$ 618.00
25 mg	In stock	$ 985.00
50 mg	In stock	$ 1,330.00
100 mg	In stock	$ 1,790.00
500 mg	In stock	$ 3,590.00
1 mL * 10 mM (in DMSO)	In stock	$ 457.00

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Purity: 99.96%

Purity: 99.36%

Purity: 98.68%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.
Targets&IC50	PARP7:1 nM (Kd), PARP7:3 nM (IC50)
In vitro	Inhibition of PARP7 with RBN-2397 can potently inhibit the growth of cancer cells and restore interferon signaling, effectively releasing the brake cancer uses to hide from the immune system and suppress both innate and adaptive immune mechanisms.RBN-2397 inhibits cells proliferation(IC50 value of 20 nM in NCI-H1373 lung cancer cells), shows a restoration of type I IFN response by an increase in STAT1 phosphorylation as a dose-dependent manner in NCI-H1373 human lung cancer cells,and inhibits cell MARylation in a cell biochemial assay with an EC50 value of 1 nM[2].
In vivo	RBN-2397 oral administration induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses in CT26 tumor-bearing BALB/c mice.RBN-2397 oral administration causes complete regressions at the dose 100 mg/kg and exerts a dose-dependent effects on tumor growth at dose levels of ≥30 mg/kg.The half-life (t1/2) of RBN-2397 in vivo is 325 mins[2].

Molecular Weight	523.43
Formula	C20H23F6N7O3
CAS No.	2381037-82-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 247 mg/mL (471.89 mM), Sonication is recommended.

References and Literature

2. Melissa Vasbinder, et al. RBN-2397: A First-in-Class PARP7 Inhibitor Targeting a Newly Discovered Cancer Vulnerability in Stress-Signaling Pathways.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library DNA Damage & Repair Compound Library Anti-Cardiovascular Disease Compound Library Clinical Compound Library Bioactive Compounds Library Max Anti-Prostate Cancer Compound Library

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Related compounds with same targets

PARP14 inhibitor H10 Fucosterol IVHD-valtrate PARP-1-IN-13 Dehydrocavidine WIKI4 Veliparib dihydrochloride Simmiparib

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RBN-2397 2381037-82-5 Chromatin/Epigenetic DNA Damage/DNA Repair PARP inhibit carcinoma Inhibitor RBN2397 NSCLC advanced metastatic squamous cell RBN 2397 ovarian poly ADP ribose polymerase solid tumor lung inhibitor

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