Home Tools
Log in
Cart

Imiquimod

Catalog No. T0134   CAS 99011-02-6
Synonyms: R 837, S-26308

Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Imiquimod Chemical Structure
Imiquimod, CAS 99011-02-6
Pack Size Availability Price/USD Quantity
50 mg In stock $ 38.00
100 mg In stock $ 50.00
200 mg In stock $ 70.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 100%
Purity: 99.31%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.
In vivo In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].
Synonyms R 837, S-26308
Molecular Weight 240.3
Formula C14H16N4
CAS No. 99011-02-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.4 mg/ml (10 mM), Sonification is recommended

H2O: Insoluble

TargetMolReferences and Literature

1. Gibson SJ, et al. Cell Immunol. 2002 Jul-Aug;218(1-2):74-86.

TargetMolCitations

1. Wang Y, Gong N, Ma C, et al. An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination. Nature Communications. 2021, 12(1): 1-16. 2. Chen X, Chen Y, Ou Y, et al. Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation. Biochemical Pharmacology. 2022, 206: 115326. 3. Chen Y, Chen X, Liang S, et al. Chlorquinaldol inhibits the activation of nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 inflammasome and ameliorates imiquimod-induced psoriasis-like dermatitis in mice. Chemico-Biological Interactions. 2022, 365: 110122. 4. Zhou Y, Yang Z, Ou Y, et al.Discovery of a selective NLRP3-targeting compound with therapeutic activity in MSU-induced peritonitis and DSS-induced acute intestinal inflammation.Cellular and Molecular Life Sciences.2023, 80(8): 230. 5. Zeng Y, Luo M, Yao Z, et al.Adiponectin inhibits ROS/NLRP3 inflammatory pathway through FOXO3A to ameliorate oral submucosal fibrosis.Odontology.2024: 1-15.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Pediatric Drug Library Clinical Compound Library Pyroptosis Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets
Adenosine 5'-monophosphate monohydrate Surfactin 20(R)-Ginsenoside Rh2 Kushenol K Guanosine (2S)-Isoxanthohumol ML324 Moronic acid

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Imiquimod 99011-02-6 Autophagy Immunology/Inflammation Microbiology/Virology SARS-CoV TLR HSV Bowen's R-837 intraepithelial carcinoma basal ,cell inhibit Toll-like Receptor (TLR) contagiosum molluscum S26308 keratosis vulvar Herpes simplex virus R 837 warts actinic infection disease R837 squamous human cell S 26308 nongenital SARS coronavirus neoplasia S-26308 papillomavirus Inhibitor inhibitor

 

TargetMol