selectivity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9339	Stafia-1		STAT
	Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.		STAT
T11960	MBM-55		GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase
	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
T21331	SAR-020106		Chk
	SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.		Chk
T9020	GSK620		Epigenetic Reader Domain
	GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD...		Epigenetic Reader Domain
T9470	HPK1-IN-7		MAPK
	HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).		MAPK
T28628	RVX-297	RVX297	Epigenetic Reader Domain
	RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein.		Epigenetic Reader Domain
T11696	Ivachtin	Caspase-3 Inhibitor VII	Caspase
	Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.		Caspase
T4199	Desmethyl-VS-5584		PI3K , mTOR
	Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.		PI3K , mTOR
T28352	PDE9-IN-(S)-C33	(S)-C33	PDE
	PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.		PDE
T5405	BI-1347		CDK
	BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.		CDK
T9564	IRE1α kinase-IN-1		IRE1
	IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph...		IRE1
T1885	Siramesine hydrochloride	Lu 28-179 hydrochloride	Ferroptosis , Sigma receptor , lysosomal autophagy
	Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.		Ferroptosis , Sigma receptor , lysosomal autophagy
T15418	GS-6201	CVT-6883	Adenosine Receptor
	GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM.		Adenosine Receptor
T0185	Escitalopram	Seroplex,S-(+)-Citalopram,(S)-Citalopram	Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
	Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patien...
T6658	SB-408124		OX Receptor
	SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.		OX Receptor
T6493	Escitalopram Oxalate	Cipralex,(S)-(+)Citalopram oxalate	Others , 5-HT Receptor , Serotonin Transporter
	Escitalopram Oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.		Others , 5-HT Receptor , Serotonin Transporter
T4620	Siramesine	Lu 28-179	Sigma receptor
	Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram...		Sigma receptor
T14547	JWG-071	JWG071,JWG 071	ERK , Epigenetic Reader Domain
	JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity.		ERK , Epigenetic Reader Domain
T6940	PHA-767491 hydrochloride	CAY10572,PHA-767491,PHA767491 HCl,CAY-10572 hydrochloride	Apoptosis , GSK-3 , CDK
	PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK...		Apoptosis , GSK-3 , CDK
T14947	CHDI-390576		HDAC
	CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity ...		HDAC