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Siramesine hydrochloride

Catalog No. T1885 CAS 224177-60-0

Synonyms: 西拉美新盐酸盐, Lu 28-179 hydrochloride

Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.

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Siramesine hydrochloride, CAS 224177-60-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Siramesine (Lu 28-179) hydrochloride is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.

Synonyms	西拉美新盐酸盐, Lu 28-179 hydrochloride
Molecular Weight	491.05
Formula	C30H32ClFN2O
CAS No.	224177-60-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 42 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cesen MH, et al. Cell Death Dis. 2013 Oct 3;4:e818.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library Autophagy Compound Library GPCR Compound Library Neurotransmitter Receptor Compound Library Mitochondria-Targeted Compound Library Fluorochemical Library Anti-Cancer Active Compound Library Anti-COVID-19 Compound Library Apoptosis Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Siramesine hydrochloride 224177-60-0 G蛋白偶联受体凋亡细胞周期自噬 Ferroptosis lysosomal autophagy Sigma receptor Sigma Receptor mitochondria cathepsin selectivity lysosomes Siramesine Inhibitor Lu 28-179 inhibit cancer Lu 28-179 hydrochloride death inhibitor

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