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BI-1347

BI-1347
BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.
Catalog No. T5405Cas No. 2163056-91-3
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Purity:99.43%
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BI-1347

Catalog No. T5405Cas No. 2163056-91-3
BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
5 mg$80In Stock
10 mg$128In Stock
25 mg$253In Stock
50 mg$463In Stock
100 mg$682In Stock
500 mg$1,430In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Product Introduction

Bioactivity
Description
BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.
Targets&IC50
CDK8:1 nM (cell free)
Chemical Properties
Molecular Weight356.42
FormulaC22H20N4O
Cas No.2163056-91-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 120 mg/mL (336.68 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8057 mL14.0284 mL28.0568 mL140.2839 mL
5 mM0.5611 mL2.8057 mL5.6114 mL28.0568 mL
10 mM0.2806 mL1.4028 mL2.8057 mL14.0284 mL
20 mM0.1403 mL0.7014 mL1.4028 mL7.0142 mL
50 mM0.0561 mL0.2806 mL0.5611 mL2.8057 mL
100 mM0.0281 mL0.1403 mL0.2806 mL1.4028 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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