function — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15052	Dapansutrile		NOD-like Receptor (NLR) , NOD
	Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.		NOD-like Receptor (NLR) , NOD
T5692	Pyrroloquinoline quinone		Others , Endogenous Metabolite
	Pyrroloquinoline quinone (PQQ), as a well-known redox enzyme cofactor, PQQ can protect NS/PCs against glutamate toxicity associated with ROS-mediated mitochondrial pathway,		Others , Endogenous Metabolite
T4304	Azoramide		Apoptosis , PERK
	Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response.		Apoptosis , PERK
T6778	BDA-366		BCL
	BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-ap...		BCL
T4534	BMS-309403		FABP
	BMS-309403 is an effective, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.		FABP
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T4S1114	Dryocrassin ABBA	Dryocrassin	Influenza Virus , Antibacterial
	Dryocrassin ABBA (Dryocrassin) is a flavonoid natural product derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities.		Influenza Virus , Antibacterial
T4612	NS309		EGFR , Potassium Channel , HER
	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...		EGFR , Potassium Channel , HER
T15050	Danicamtiv	MYK-491,SAR 440181	Myosin
	Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.		Myosin
T60080	TMPH	2,2,6,6-Tetramethylpiperidin-4-yl heptanoate	AChR
	TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders.		AChR
T4478	CID 16020046	C390-0219	Cannabinoid Receptor
	CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.		Cannabinoid Receptor
T8364	Mebrofenin	SQ 26962	Others
	Mebrofenin (SQ 26962) is available as a ready to use the kit for radio-labeling with Tc-99m.Technetium Tc 99m Mebrofenin is a diagnostic radiopharmaceutical composed of diisopropyl-iminodiacetic acid (DISIDA) attached to...		Others
T5693	Pyrroloquinoline quinone disodium salt	Methoxatin disodium salt	Others , Endogenous Metabolite
	Pyrroloquinoline quinone disodium salt (Methoxatin disodium salt), an aromatic tricyclic o-quinone, is a redox cofactor for bacterial dehydrogenases. It is an efficient electron transfer catalyst from a number of organic...		Others , Endogenous Metabolite
T17143	Toyocamycin	Vengicide	Apoptosis , Others , IRE1 , Antibiotic , Antifungal
	Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.		Apoptosis , Others , IRE1 , Antibiotic , Antifungal
T7486	Imeglimin hydrochloride	EMD 387008 hydrochloride	Reactive Oxygen Species , Mitochondrial Metabolism
	Imeglimin hydrochloride (EMD 387008 hydrochloride) prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.		Reactive Oxygen Species , Mitochondrial Metabolism
T9112	(-)-Perillaldehyde		AhR , ROS , Nrf2
	(-)-Perillaldehyde shows antibacterial activity.		AhR , ROS , Nrf2
T34406	RS 0481	RS-0481,RS0481
	RS 0481 can re-establish the function of certain lymphoid cell populations impaired by the presence of a growing tumor in an animal.
TCO2745	Cyclic AMP	Adenosine 3',5'-cyclophosphate,cAMP,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate	Others , Endogenous Metabolite
	Cyclic AMP (cAMP) (Adenosine 3',5'-cyclophosphate) combined with vitamin C treatment of children with viral myocarditis has exact curative effect, and it can improve cardiac function of patients and improve immune functi...		Others , Endogenous Metabolite
T9947	GW-6604		PAI-1 , ALK , TGF-beta/Smad
	GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.		PAI-1 , ALK , TGF-beta/Smad
T40108	Inaxaplin	VX-147	Others
	Inaxaplin is an apolipoprotein L1 ( APOL1 ) function inhibitor. Inaxaplin can be used for the research of kidney disease.		Others