Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 328.00 | |
50 mg | In stock | $ 489.00 | |
100 mg | In stock | $ 713.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement. |
In vitro | GW-6604 inhibited autophosphorylation of ALK5 with an IC50 of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC50 = 500 nM)[2]. |
In vivo | GW-6604 (40 mg/kg p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. In an acute model of liver disease, GW-6604 reduced by 80% the expression of collagen IA1. In a chronic model of DMN-induced fibrosis where DMN was administered for 6 weeks and GW-6604 dosed for the last 3 weeks (80 mg/kg p.o., b.i.d.), mortality was prevented and DMN-induced elevations of mRNA encoding for collagen IA1, IA2, III, TIMP-1 and TGF-beta were reduced by 50-75%. Inhibition of matrix genes overexpression was accompanied by reduced matrix deposition and reduction in liver function deterioration, as assessed by bilirubin and liver enzyme levels[2]. |
Molecular Weight | 298.34 |
Formula | C19H14N4 |
CAS No. | 452342-37-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.98 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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GW-6604 452342-37-9 Angiogenesis Metabolism Stem Cells Tyrosine Kinase/Adaptors PAI-1 ALK TGF-beta/Smad GW6604 GW 6604 inhibitor inhibit