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Membrane transporter/Ion channel Potassium Channel NS309

NS309

Catalog No. T4612   CAS 18711-16-5

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 µM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.

NS309, CAS 18711-16-5
Pack Size Availability Price/USD Quantity
5 mg In stock 54.00
10 mg In stock 71.00
25 mg In stock 152.00
50 mg In stock 235.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Purity 95.87%
Biological Description
Chemical Properties
Storage & Solubility Information
Description NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 µM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.
Targets&IC50 Potassium Channel ,   hERG
Molecular Weight 231.04
Formula C8H4Cl2N2O2
CAS No. 18711-16-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 50 mg/mL (216.41 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Stankevicius, Edgaras; Dalsgaard, Thomas; Kroigaard, Christel et al. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizin 2. Seear, Rachel V.; Lew, Virgilio L. IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent. Cell Calcium (2011), 50(5), 444-448. 3. Dalsgaard, T.; Kroigaard, C.; Misfeldt, M. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. British Journal of Pharmacology (2010), 160(6), 1496-1508 4. Broendum, E.; Kold-Petersen, H.; Simonsen, U.; Aalkjaer, C. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. British Journal of Pharmacology (2010), 159(1), 154-165.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Clinical Compound Library

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