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NS309

Catalog No. T4612 CAS 18711-16-5

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 μM for SK channels and 10-90 nM for IK channels). It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 μM), but does not, however, affect large conductance (BK/KCa1.1) channels. NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects. It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO and often used in conjunction with CyPPA to distinguish between SK1 and SK3 subtypes.

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NS309, CAS 18711-16-5

Pack Size	Availability	Price/USD
5 mg	In stock	$ 52.00
10 mg	In stock	$ 63.00
25 mg	In stock	$ 122.00
50 mg	In stock	$ 228.00
100 mg	In stock	$ 339.00
200 mg	In stock	$ 495.00
500 mg	In stock	$ 791.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 95.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

ERG (human):1 µM

Molecular Weight	231.04
Formula	C8H4Cl2N2O2
CAS No.	18711-16-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (216.41 mM)

References and Literature

1. Stankevicius, Edgaras; Dalsgaard, Thomas; Kroigaard, Christel et al. Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizin 2. Seear, Rachel V.; Lew, Virgilio L. IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent. Cell Calcium (2011), 50(5), 444-448. 3. Dalsgaard, T.; Kroigaard, C.; Misfeldt, M. Openers of small conductance calcium-activated potassium channels selectively enhance NO-mediated bradykinin vasodilatation in porcine retinal arterioles. British Journal of Pharmacology (2010), 160(6), 1496-1508 4. Broendum, E.; Kold-Petersen, H.; Simonsen, U.; Aalkjaer, C. NS309 restores EDHF-type relaxation in mesenteric small arteries from type 2 diabetic ZDF rats. British Journal of Pharmacology (2010), 159(1), 154-165.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Cytokine Inhibitor Library Ion Channel Inhibitor Library Angiogenesis related Compound Library Preclinical Compound Library Bioactive Compound Library Anti-Liver Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Lung Cancer Compound Library Potassium Channel Blocker Library

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Keywords

NS309 18711-16-5 Angiogenesis JAK/STAT signaling Membrane transporter/Ion channel Tyrosine Kinase/Adaptors Potassium Channel EGFR HER SCI/R spinal neuronal NS 309 overactive erectile OAB function KcsA NS-309 Inhibitor ischemia-reperfusion bladder cord hyperexcitability inhibit injury inhibitor

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