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BDA-366

Name: BDA-366
Brand: TargetMol
SKU: T6778
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6778Cas No. 1909226-00-1

BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-apoptotic entity. This compound effectively suppresses lung cancer cell growth[1].

BDA-366

🥰Excellent

Purity: 98.61%

Catalog No. T6778Cas No. 1909226-00-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	In Stock	In Stock
5 mg	$110	In Stock	In Stock
10 mg	$187	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$636	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Questions

Batch Information

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Purity:98.61%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-apoptotic entity. This compound effectively suppresses lung cancer cell growth[1].
Targets&IC50	Bcl-2:3.3 nM (Ki)
In vitro	NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3].

Chemical Properties

Molecular Weight	423.5
Formula	C₂₄H₂₉N₃O₄
Cas No.	1909226-00-1
Smiles	N(C[C@H]1CO1)C2=C3C(=C(NC[C@@H](CN(CC)CC)O)C=C2)C(=O)C=4C(C3=O)=CC=CC4
Relative Density.	1.313 g/cm3 (Predicted)
Color	Blue
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 5 mg/mL (11.81 mM), Sonication is recommended.

DMSO: 78 mg/mL (184.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.79 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3613 mL	11.8064 mL	23.6128 mL	118.0638 mL
5 mM	0.4723 mL	2.3613 mL	4.7226 mL	23.6128 mL
10 mM	0.2361 mL	1.1806 mL	2.3613 mL	11.8064 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1181 mL	0.5903 mL	1.1806 mL	5.9032 mL
50 mM	0.0472 mL	0.2361 mL	0.4723 mL	2.3613 mL
100 mM	0.0236 mL	0.1181 mL	0.2361 mL	1.1806 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc