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Pyrroloquinoline quinone

Catalog No. T5692 CAS 72909-34-3

Pyrroloquinoline quinone (PQQ), as a well-known redox enzyme cofactor, PQQ can protect NS/PCs against glutamate toxicity associated with ROS-mediated mitochondrial pathway,

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Pyrroloquinoline quinone Chemical Structure

Pyrroloquinoline quinone, CAS 72909-34-3

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Purity: 98%

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Description	Pyrroloquinoline quinone (PQQ), as a well-known redox enzyme cofactor, PQQ can protect NS/PCs against glutamate toxicity associated with ROS-mediated mitochondrial pathway,
In vitro	Pyrroloquinoline quinone(PQQ) pretreatment showed its significant effect on protecting NS/PCs against glutamate-induced apoptosis/necrosis.?PQQ neuroprotection was associated with the decrease of intracellular reactive oxygen species (ROS) production, the increase of glutathione (GSH) levels, and the decrease of caspase-3 activity.?In addition, pretreatment with PQQ also significantly enhanced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the NS/PCs exposed to glutamate[1].
In vivo	Pyrroloquinoline quinone(PQQ), a natural anti-oxidant present in a wide variety of human foods, exerted potent anti-fibrotic and ROS-scavenging activity in Balb/C mouse models of liver fibrosis. The antioxidant activity of PQQ was involved in the modulation of multiple steps during liver fibrogenesis, including chronic liver injury, hepatic inflammation, as well as activation of hepatic stellate cells and production of extracellular matrix. PQQ also suppressed the up-regulation of RACK1 in activated HSCs in vivo and in vitro. PQQ suppresses oxidative stress and liver fibrogenesis in mice[2].
Animal Research	Healthy male Balb/C mice of 4–6 week were used to induce liver fibrosis and isolate primary HSCs.?The animals were obtained from SLAC Laboratory Animal Corp in SPF microbiological status.?All mice were maintained at 25°C with a 12 h dark/light cycle and completely randomly grouped.?For thioacetamide (TAA)-induced liver fibrosis, which has been shown to be closely resemble the panlobular and parenchymal fibrosis that is found in most human chronic liver disease , TAA was given by intraperitoneal injection ?at 200 mg/kg body weight 3 times each week for 8 weeks.?For bile duct ligation (BDL)-induced liver fibrosis, BDL was performed according to previous report , and mice were sacrificed 2 weeks later.?Administration of PQQ started on the second day when TAA was firstly given or BDL was performed, and PQQ was given at the dose of 0.3 mg/kg or 1 mg/kg by gastrogavage administration daily before mice were sacrificed.?Silymarin (150 mg/kg) was used as the positive control by gastrogavage administration daily.?Total number of 405 mice were used.?Mice were sacrificed by cervical dislocation under anesthesia[2].

Molecular Weight	330.21
Formula	C14H6N2O8
CAS No.	72909-34-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.75 mg/mL (8.33 mM), Sonication is recommended.

H2O: 0.2 mg/mL (0.61 mM), Sonication is recommended.

References and Literature

1. Guan S , Xu J , Guo Y , et al. Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells[J]. International Journal of Developmental Neuroscience, 2015, 42:37-45. 2. Dongwei J , Fangfang D , Peike P , et al. Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice[J]. PLOS ONE, 2015, 10(3):e0121939-. 3. Saihara K, Kamikubo R, Ikemoto K,et al.Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway[J].Biochemistry. 2017 Dec 19;56(50):6615-6625.

Related compound libraries

This product is contained In the following compound libraries：

Microbial Natural Product Library Natural Product Library for HTS Bioactive Compound Library Human Metabolite Library Bioactive Compounds Library Max Natural Product Library RO5 Drug-like Natural Product Library Human Endogenous Metabolite Compound Library Plus

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Keywords

Pyrroloquinoline quinone 72909-34-3 Metabolism Others Endogenous Metabolite essential redox anionic inhibit Methoxatin co-factor PQQ bacteria function methylotropic immune nutrient Inhibitor inhibitor

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