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CID 16020046

Catalog No. T4478 CAS 834903-43-4

Synonyms: C390-0219

CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.

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CID 16020046, CAS 834903-43-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 56.00
5 mg	In stock	$ 92.00
10 mg	In stock	$ 145.00
25 mg	In stock	$ 246.00
50 mg	In stock	$ 363.00
100 mg	In stock	$ 539.00
1 mL * 10 mM (in DMSO)	In stock	$ 109.00

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Purity: 99.59%

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Description	CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.
Targets&IC50	GPR55:0.15 μM
In vitro	In yeast cells expressing human GPR55, CID16020046 inhibited agonist-induced receptor activation. In human embryonic kidney (HEK293) cells stably expressing human GPR55, CID16020046 behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2 (CB1 or CB2). CID16020046 dose-dependently inhibited lysophosphatidylinositol (LPI)-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor κ of activated B cells (NF-κB) and serum response element, translocation of NFAT and NF-κB, and GPR55 internalization [1].

Synonyms	C390-0219
Molecular Weight	425.44
Formula	C25H19N3O4
CAS No.	834903-43-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL

References and Literature

1. Kargl J, et al. A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Alzheimer's Disease Compound Library Endocrinology-Hormone Compound Library Bioactive Compounds Library Max Bioactive Compound Library NO PAINS Compound Library Anti-Cancer Compound Library

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Keywords

CID 16020046 834903-43-4 GPCR/G Protein Cannabinoid Receptor cells wound Ca2+ inhibit ERK1/2 GPR55 hERG acetylcholinesterase HEK function phosphorylation KCNH2 LPI healing endothelial platelet Inhibitor HMVEC lysophosphatidylinositol C390-0219 m-opioid G protein-coupled receptor 55 CID16020046 CID-16020046 inhibitor

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