cyclooxygenase-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T0649	Salicylic acid	2-Hydroxybenzoic acid	Apoptosis , Mitophagy , COX , Endogenous Metabolite , Autophagy
	Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
T4643	TFAP	N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide	COX , Endogenous Metabolite
	TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a selective cyclooxygenase-1 (COX-1) inhibitor		COX , Endogenous Metabolite
T1301	Guaiacol	O-methylcatechol,2-hydroxyanisole,o-methoxyphenol,2-Methoxyphenol	NF-κB , COX , Endogenous Metabolite
	Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator...		NF-κB , COX , Endogenous Metabolite
T6S0413	Pectolinarigenin	Pectolinaringenin	Others , Lipoxygenase , COX
	1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ...		Others , Lipoxygenase , COX
T3214	NS-398	N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide,NS398	COX
	NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a COX-2 inhibitor wih anti-inflammatory activity.		COX
T0432	Diclofenac diethylamine		Apoptosis , COX
	Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).		Apoptosis , COX
T7207	FK 3311	FK-3311,COX-2 Inhibitor V	COX
	FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)		COX
T8356	FPL 62064		Lipoxygenase , COX
	FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).		Lipoxygenase , COX
T3399	Psoralidin		Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T22368	Metyrosine	α-Methyltyrosine	COX
	Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressu...		COX
T0399	Methyl salicylate	Gaultheria oil,Methyl 2-hydroxybenzoate,2-Carbomethoxyphenol,Betula oil,Natural wintergreen oil,Wintergreen oil	COX , TRP/TRPV Channel
	Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic ...		COX , TRP/TRPV Channel
T7838	Losartan Carboxaldehyde		COX
	Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.		COX
T7596	Firocoxib	ML 1785713	COX
	Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.		COX
TN2139	Regaloside B		NOS , COX , NO Synthase
	Regaloside B, a phenylpropanoid isolated from Lilium longiflorum, exhibits anti-inflammatory activity by inhibiting the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2).		NOS , COX , NO Synthase
T3779	Crocin II	Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B	Caspase , COX , NO Synthase
	Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...		Caspase , COX , NO Synthase
T0458	Indomethacin	Indocin,Indometacine,Indomethacine,Indometacin	Phospholipase , COX , PDE , Autophagy
	Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.		Phospholipase , COX , PDE , Autophagy
T5758	Sphondin		COX , Prostaglandin Receptor
	Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.		COX , Prostaglandin Receptor
T8656	CAY10404	3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis , Akt , COX
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cel...		Apoptosis , Akt , COX