Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 38.00 | |
5 mg | In stock | $ 61.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 168.00 | |
50 mg | In stock | $ 263.00 | |
100 mg | In stock | $ 393.00 | |
200 mg | In stock | $ 576.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 81.00 |
Description | FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID) |
In vivo | Survival rate was significantly better (p <0.05) and serum GOT levels 30 min after reperfusion were significantly lower (p <0.05) in the FK 3311(FK) high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly (p <0.05) better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control (p <0.05)[1]. |
Animal Research | Inbred male Lewis rats weighing 200-260 g were used. The donor liver was perfused with cold University of Wisconsin (UW) solution and then stored in the same solution at 4 degrees C for 18 hr. After the preservation period, orthotopic liver transplantation was performed. Animals were divided into three groups: the control group; the FK low-dose group (1 mg/kg FK3311 i.v. 20 min before reperfusion); and the FK high-dose group (3 mg/kg FK3311. 20 min before reperfusion). Survival rate, serum GOT and GPT levels, liver tissue blood flow, and serum thromboxane B(2) (TxB(2)) levels were compared among groups[1]. |
Synonyms | FK-3311, COX-2 Inhibitor V |
Molecular Weight | 341.33 |
Formula | C15H13F2NO4S |
CAS No. | 116686-15-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (292.97 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
FK 3311 116686-15-8 Immunology/Inflammation Neuroscience COX Cyclooxygenase FK3311 Inhibitor inhibit FK-3311 COX-2 Inhibitor V inhibitor