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FK 3311

Catalog No. T7207   CAS 116686-15-8
Synonyms: FK-3311, COX-2 Inhibitor V

FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
FK 3311 Chemical Structure
FK 3311, CAS 116686-15-8
Pack Size Availability Price/USD Quantity
2 mg In stock $ 38.00
5 mg In stock $ 61.00
10 mg In stock $ 97.00
25 mg In stock $ 168.00
50 mg In stock $ 263.00
100 mg In stock $ 393.00
200 mg In stock $ 576.00
1 mL * 10 mM (in DMSO) In stock $ 81.00
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Purity: 97.3%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)
In vivo Survival rate was significantly better (p <0.05) and serum GOT levels 30 min after reperfusion were significantly lower (p <0.05) in the FK 3311(FK) high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly (p <0.05) better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control (p <0.05)[1].
Animal Research Inbred male Lewis rats weighing 200-260 g were used. The donor liver was perfused with cold University of Wisconsin (UW) solution and then stored in the same solution at 4 degrees C for 18 hr. After the preservation period, orthotopic liver transplantation was performed. Animals were divided into three groups: the control group; the FK low-dose group (1 mg/kg FK3311 i.v. 20 min before reperfusion); and the FK high-dose group (3 mg/kg FK3311. 20 min before reperfusion). Survival rate, serum GOT and GPT levels, liver tissue blood flow, and serum thromboxane B(2) (TxB(2)) levels were compared among groups[1].
Synonyms FK-3311, COX-2 Inhibitor V
Molecular Weight 341.33
Formula C15H13F2NO4S
CAS No. 116686-15-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (292.97 mM)

TargetMolReferences and Literature

1. Oshima K , Yabata Y , Yoshinari D , et al. The Effects of Cyclooxygenase (COX)-2 Inhibition on Ischemia-Reperfusion Injury in Liver Transplantation[J]. Journal of Investigative Surgery, 2009, 22(4):239-245.

Related compound libraries

This product is contained In the following compound libraries:
Angiogenesis related Compound Library Neuronal Signaling Compound Library HIF-1 Signaling Pathway Compound Library Anti-Pancreatic Cancer Compound Library NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library Mitochondria-Targeted Compound Library Anti-Aging Compound Library Anti-Prostate Cancer Compound Library Bioactive Compounds Library Max

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Keywords

FK 3311 116686-15-8 Immunology/Inflammation Neuroscience COX Cyclooxygenase FK3311 Inhibitor inhibit FK-3311 COX-2 Inhibitor V inhibitor

 

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