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Salicylic acid

Catalog No. T0649 CAS 69-72-7

Synonyms: 2-Hydroxybenzoic acid

Salicylic acid, a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.

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Salicylic acid, CAS 69-72-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Salicylic acid, a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.
In vitro	Salicylic acid (SA) is a phenolic phytohormone involved in plant defence against pathogens. It significantly stimulated PON1 activity in a concentration dependent manner[3].
In vivo	Although oral SA (5.5 mg/kg body weight) during the Hg(0) exposure did not reduce the Hg levels in these organs, it effectively counteracted the Hg(0)-induced growth inhibition, and improved the behavioral performance, accompanied by a series of ameliorations in the antioxidative defense and anti-inflammatory response[2].

Synonyms	2-Hydroxybenzoic acid
Molecular Weight	138.12
Formula	C7H6O3
CAS No.	69-72-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 195.5 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mitchell JA, et al. Mol Pharmacol. 1997, 51(6):907-912. 2. Ma C, et al. Inhal Toxicol. 2013, 25(7):398-404. 3. Mouhamed, et al. J Drug Metab Toxicol. 2013, 4:2. 4. Leslie CA, et al. Plant Physiol. 1988, 88(3):833-837.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Salicylic acid 69-72-7 Apoptosis Autophagy Immunology/Inflammation Metabolism Neuroscience COX Endogenous Metabolite Mitophagy Inhibitor Cyclooxygenase inhibit Mitochondrial Autophagy 2-Hydroxybenzoic acid inhibitor

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