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FPL 62064

Catalog No. T8356   CAS 103141-09-9

FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).

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FPL 62064 Chemical Structure
FPL 62064, CAS 103141-09-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 56.00
5 mg In stock $ 122.00
10 mg In stock $ 197.00
25 mg In stock $ 427.00
50 mg In stock $ 648.00
100 mg In stock $ 923.00
1 mL * 10 mM (in DMSO) In stock $ 169.00
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Purity: 99.64%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).
Targets&IC50 RBL-1 cytosolic 5-lipoxygenase:3.5 μM , prostaglandin synthetase:3.1 μM
In vivo FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation.
Animal Research Animal Model:Female LACA mice (20-30 g) injected with immune complex. Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg. Administration:Intraperitoneal injection.
Molecular Weight 265.31
Formula C16H15N3O
CAS No. 103141-09-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (942.29 mM), sonification is recommended.

TargetMolReferences and Literature

1. Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42. 2. Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308.

Related compound libraries

This product is contained In the following compound libraries:
Metabolism Compound Library Neuronal Signaling Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Inhibitor Library Anti-Metabolism Disease Compound Library Ferroptosis Compound Library Lipid Metabolism Compound Library

Related Products

Related compounds with same targets
4-MMPB Nordihydroguaiaretic acid Malotilate COX-2/15-LOX-IN-2 COX-2/15-LOX-IN-3 COX-2/15-LOX-IN-4 11-​Keto-​beta-​boswellic acid 5-Lipoxygenase-In-1

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Keywords

FPL 62064 103141-09-9 Immunology/Inflammation Metabolism Neuroscience COX Lipoxygenase Cyclooxygenase LOX 5-lipoxygenase inhibit Prostaglandin 5-LOX FPL62064 Inhibitor synthetase anti-inflammatory COX-2 FPL-62064 inhibitor

 

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