Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 56.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 427.00 | |
50 mg | In stock | $ 648.00 | |
100 mg | In stock | $ 923.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 169.00 |
Description | FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively). |
Targets&IC50 | RBL-1 cytosolic 5-lipoxygenase:3.5 μM , prostaglandin synthetase:3.1 μM |
In vivo | FPL 62064 inhibited UV irradiation-induced erythema and PGE2 formation in the guinea pig and also oedema formation and eicosanoid production in the mouse ear produced by arachidonic acid. Co-injected with arachidonic acid in rabbit skin, FPL 62064 inhibited oedema and eicosanoid formation. |
Animal Research | Animal Model:Female LACA mice (20-30 g) injected with immune complex. Dosage:5 mg/kg, 10 mg/kg, 20 mg/kg. Administration:Intraperitoneal injection. |
Molecular Weight | 265.31 |
Formula | C16H15N3O |
CAS No. | 103141-09-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (942.29 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
FPL 62064 103141-09-9 Immunology/Inflammation Metabolism Neuroscience COX Lipoxygenase Cyclooxygenase LOX 5-lipoxygenase inhibit Prostaglandin 5-LOX FPL62064 Inhibitor synthetase anti-inflammatory COX-2 FPL-62064 inhibitor