Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cells, with analgesic, anti-inflammatory and anti-cancer activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 312.00 | |
50 mg | In stock | $ 531.00 | |
100 mg | In stock | $ 768.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cells, with analgesic, anti-inflammatory and anti-cancer activities. |
Targets&IC50 | COX-1:>500 μM, COX-2:1 nM |
In vitro | Treatment with CAY10404 in the range of 10-100 microM caused dose-dependent growth inhibition, with an average 50% inhibitory concentration (IC(50)) of 60-100 micromol/L, depending on the cell line.?Western blot analysis of CAY10404-treated cells showed cleavage of poly (ADP-ribose) polymerase (PARP) and procaspase-3, signifying caspase activity and apoptotic cell death.?CAY10404 treatment inhibited the phosphorylation of Akt, glycogen synthase kinase-3beta and extracellular signal-regulated kinases 1/2 in H460 and H358 cells[1] |
Cell Research | To measure the effects of CAY10404 on proliferation of NSCLC cells, 3 x 10(3) cells/well were plated in 96-well plates and allowed to adhere overnight at 37 degrees C. After treatment with CAY10404 for 3 days, cell proliferation was measured by the 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In the H460 NSCLC cells, evidence of apoptosis was sought using the terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labelling (TUNEL) assay and western blot analysis[1]. |
Synonyms | 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Molecular Weight | 367.34 |
Formula | C17H12F3NO3S |
CAS No. | 340267-36-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (27.22 mM)
You can also refer to dose conversion for different animals. More
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CAY10404 340267-36-9 Apoptosis Cytoskeletal Signaling Immunology/Inflammation Neuroscience PI3K/Akt/mTOR signaling Akt COX Bcl-XL cancer anti-inflammatory Bcl-2 H-1703 Cyclooxygenase CAY-10404 NSCLC H-358 inhibit cell pGSK-3β H-460 analgesic 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T MAPK cyclooxygenase-2 lung anti-cancer Inhibitor Non-small CAY 10404 Protein kinase B pAkt PKB inhibitor