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Indomethacin

Catalog No. T0458   CAS 53-86-1
Synonyms: Indocin, Indometacine, Indomethacine, Indometacin

Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.

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Indomethacin Chemical Structure
Indomethacin, CAS 53-86-1
Pack Size Availability Price/USD Quantity
1 g In stock $ 50.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.84%
Purity: 99.27%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
Targets&IC50 COX1:0.28 μM, COX-2:14 μM
Synonyms Indocin, Indometacine, Indomethacine, Indometacin
Molecular Weight 357.79
Formula C19H16ClNO4
CAS No. 53-86-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35.8 mg/mL (100 mM)

Ethanol: 17.9 mg/mL (50 mM)), with gentle warming

TargetMolReferences and Literature

1. Dihlmann S, et al. Oncogene, 2001, 20(5), 645-653. 2. Hoehn BD, et al. Stroke, 2005, 36(12), 2718-2724. 3. Yamada T, et al. Inflammation, 1993, 17(6), 641-662. 4. Fischer SM, et al. Mol Carcinog, 1999, 25(4), 231-240. 5. Yoshikawa T, et al. Gut, 1993, 34(6), 732-737. 6. Lopes RS, et al. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. J Biosci. 2016 Sep;41(3):381-94. 7. Afroz S, et al. Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer. J Agric Food Chem. 2016 Aug 26. 8. Qixiong Zhang, et al. Structure-Property Correlations of Reactive Oxygen Species-Responsive and Hydrogen Peroxide-Eliminating Materials with Anti-Oxidant and Anti-Inflammatory Activities. Chem Mater. 2017, 29(19):8221-8238. 9. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms[J]. Evidence-Based Complementary and Alternative Medicine. 2020, 2020.

TargetMolCitations

1. Bi X, Yan X, Jiang B, et al. Indoprofen exerts a potent therapeutic effect against sepsis by alleviating high mobility group box 1-mediated inflammatory responses. Toxicology and Applied Pharmacology. 2021: 115778. 2. Chen F, Xu Y, Wang J, et al. Relaxation Effect of Patchouli Alcohol in Rat Corpus Cavernous and Its Underlying Mechanisms. Evidence-Based Complementary and Alternative Medicine. 2020. 3. Yan Z, Ruan B, Wang S, et al.RNA-binding Protein QKI Inhibits Osteogenic Differentiation Via Suppressing Wnt Pathway.Archives of Medical Research.2023: 102853.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Autophagy Compound Library Bioactive Compound Library Toxic Compound Library NO PAINS Compound Library Anti-Obesity Compound Library Anti-Aging Compound Library

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Indomethacin 53-86-1 Autophagy Immunology/Inflammation Metabolism Neuroscience COX Phospholipase PDE inflammation Indocin inhibit COX-2 anticancer Indometacine anti-infective Inhibitor Indomethacine Cyclooxygenase Indometacin COX-1 inhibitor

 

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