anti-obesity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3672	Nomilin		MAPK
	Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.		MAPK
T5751	Tigogenin		Others
	Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.		Others
T5778	5,7-DIMETHOXYFLAVONE		Anti-infection , P450
	5,7-DIMETHOXYFLAVONE possessed remarkable leishmanicidal potential.		Anti-infection , P450
T7704	KY-226		Phosphatase
	KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)		Phosphatase
T5583	Turanose	D-(+)-Turanose	Endogenous Metabolite
	D(+)-Turanose (D-(+)-Turanose) is a naturally occuring compound. It is a reducing disaccharide.		Endogenous Metabolite
T3283	Cetilistat	ATL-962	Lipid
	Cetilistat (ATL-962) is a novel inhibitor of pancreatic lipase being developed by Alizyme for the treatment of obesity and associated co-morbidities, including type 2 diabetes.		Lipid
T8476	RSVA405	RSVA 405	AMPK , STAT , Autophagy
	RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor		AMPK , STAT , Autophagy
T0686	Orlistat	Ro-18-0647,Tetrahydrolipstatin	Apoptosis , Others , Fatty Acid Synthase
	Orlistat (Tetrahydrolipstatin) is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor.		Apoptosis , Others , Fatty Acid Synthase
T3675	1-Deoxynojirimycin	Duvoglustat,Moranoline,moranolin	PI3K , Glucosidase
	1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.		PI3K , Glucosidase
T0839	Ketoprofen	RP-19583	Apoptosis , COX , MRP
	Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas...		Apoptosis , COX , MRP
TN3500	Beta-Amyrone	β-Amyron	COX , AChR , PPAR , Antifection
	beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits a...		COX , AChR , PPAR , Antifection
TN2121	3,5,7,3′,4′-Pentamethoxyflavone	Quercetin 3,5,7,3,4-pentamethyl ether	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product. It can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation.		Others
T1824	TGR5 Receptor Agonist		GPCR19
	TGR5 is a potent TGR5(GPCR19) agonist.		GPCR19
T4S1173	Agrimol B		Sirtuin , PPAR
	1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.		Sirtuin , PPAR
T21344	1-Deoxynojirimycin hydrochloride	Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin	PI3K , Antibacterial , Antibiotic , Glucosidase
	1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.		PI3K , Antibacterial , Antibiotic , Glucosidase
T11990	Meclofenamic acid	Meclofenamate	Others , Gap Junction Protein
	Meclofenamic acid (Meclofenamate) is a non-selective gap-junction blocker and a selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic acid has anti-inflammatory activities.		Others , Gap Junction Protein
T13169	TM-25659		Others
	TM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities.		Others
T7815L	AOD9604 acetate(221231-10-3 free base)	AOD-9604 acetate,AOD9604 acetate,AOD 9604 acetate	Others
	AOD9604 acetate(221231-10-3 free base) is a potential anti-obesity peptide based on the human growth hormone.		Others
T2868	Evodiamine	d-Evodiamine,Isoevodiamine,(+)-Evodiamine	Prostaglandin Receptor
	Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity and anti-tumor.		Prostaglandin Receptor
TN1803	Isoscoparin		Antioxidant , TNF , NO Synthase , Fatty Acid Synthase
	Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and treatment of obesity.		Antioxidant , TNF , NO Synthase , Fatty Acid Synthase