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Nomilin

Catalog No. T3672   CAS 1063-77-0

Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.

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Nomilin Chemical Structure
Nomilin, CAS 1063-77-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 39.00
10 mg In stock $ 64.00
25 mg In stock $ 129.00
50 mg In stock $ 188.00
100 mg In stock $ 283.00
500 mg In stock $ 688.00
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Purity: 97.68%
Purity: 97%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
In vitro Administration of Nomilin significantly retarded endothelial cell proliferation, invasion, migration and tube formation. It also possesses anti-proliferative activity against the number of human cancer cell lines including leukemia (HL-60), ovary (SKOV-3), liver (Hep G2), cervix (HeLa), stomach (NCI-SNU-1), and breast (MCF-7)[2]. Nomilin significantly decreased TRAP-positive multinucleated cell numbers compared with the control and exhibited no cytotoxicity. It decreases bone resorption activity and downregulates osteoclast-specific genes, NFATc1 and TRAP mRNA levels. Furthermore, Nomilin suppressed MAPK signaling pathways. Thus, Nomilin has inhibitory effects on osteoclastic differentiation in vitro[3].
In vivo Nomilin is an effective inducer of gluthathione S-transferase activity in mice and to inhibit carcinogenesis in the hamster buccal pouch assay. Nomilin can shorten anaesthetic-induced sleeping time in mice, probably through a stimulant action on the central nervous system [1]. Nomilin significantly inhibited tumour-directed capillary formation. Serum proinflammatory cytokines such as IL-1β, IL-6, TNF-α and GM-CSF and also serum NO levels were significantly reduced by the treatment of nomilin. Administration of Nomilin significantly reduced the serum level of VEGF, a proangiogenic factor and increased the antiangiogenic factors TIMP-1 and IL-2 [2].
Cell Research Cell lines: HUVECs. Concentrations: 5 μg-500 μg/ml. Incubation Time: 48 h. Method:. HUVECs were seeded (5000 cells/well) in 96-well flat-bottomed titer plate and incubated for 24 h at 37 °C in 5% CO2 atmosphere. Different concentrations of Nomilin (5 μg-500 μg/ml) were added and incubated further for 48 h. Before 4 h completion of incubation, 20 μl MTT (5 mg/ml) was added. Percentage of dead cells was determined using an ELISA plate reader set to record absorbance at 570 nm.
Animal Research Animal Models: Four to six week old male C57BL/6 mice. Formulation: light paraffin oil. Dosages: 6 mg/kg, I.P.
Source
Molecular Weight 514.56
Formula C28H34O9
CAS No. 1063-77-0

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

Ethanol: Insoluble

DMSO: 50 mg/mL (97.17 mM)

TargetMolReferences and Literature

1. Battinelli L, et al. Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells.[J]. Planta Medica, 2003, 69(10):910-913. 2. Pratheeshkumar P, et al. Nomilin inhibits tumor-specific angiogenesis by downregulating VEGF, NO and proinflammatory cytokine profile and also by inhibiting the activation of MMP-2 and MMP-9[J]. European Journal of Pharmacology, 2011, 668(3):450-458. 3. Kimira Y, et al. Citrus limonoid nomilin inhibits osteoclastogenesis in vitro by suppression of NFATc1 and MAPK signaling pathways.[J]. Phytomedicine, 2015, 22(12):1120-1124.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Tumor Natural Product Library Kinase Inhibitor Library Neural Regeneration Compound Library MAPK Inhibitor Library HIF-1 Signaling Pathway Compound Library Covalent Natural Product Library Anti-Prostate Cancer Compound Library Immunology/Inflammation Compound Library Selected Plant-Sourced Compound Library Human Metabolite Library

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Keywords

Nomilin 1063-77-0 MAPK inhibit anti-hyperglycemic limonoid ischemia-reperfusion anti-obesity Inhibitor compound inhibitor

 

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