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Ketoprofen

Catalog No. T0839 CAS 22071-15-4

Synonyms: RP-19583

Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.

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Ketoprofen, CAS 22071-15-4

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500 mg	In stock	$ 45.00
1 g	In stock	$ 53.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.67%

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Description	Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.
Targets&IC50	COX-2:26 nM, COX-1:2 nM
In vitro	Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining. [1]
In vivo	Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey. [2] Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. [3] Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration. [4] Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice. [5]

Synonyms	RP-19583
Molecular Weight	254.28
Formula	C16H14O3
CAS No.	22071-15-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 48 mg/mL (188.8 mM)

DMSO: 48 mg/mL (188.8 mM)

References and Literature

1. Liu S, et al. Biochem Biophys Res Commun,2007, 364(3), 650-655. 2. Li KL, et al. J Periodontal Res, 1996, 31(8), 525-532. 3. Owens JG, et al. Equine Vet J,1995, 27(4), 296-300. 4. Ting ST, et al. J Anim Sci,2003, 81(5), 1281-1293. 5. Rao KV, et al. Carcinogenesis,1996, 17(7), 1435-1438. 6. Negus SS, et al. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain. 2015 Jun;156(6):1153-60.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Immunology/Inflammation Compound Library Anti-COVID-19 Compound Library Anti-Prostate Cancer Compound Library

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Keywords

Ketoprofen 22071-15-4 Apoptosis Immunology/Inflammation Neuroscience COX MRP RP 19583 RP-19583 white adipocytes COX inhibitor Anti-inflammatory agents HFD-induced obese mice Cyclooxygenase obesity Inhibitor inhibit RP19583 3T3-L1 cell inhibitor

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