anti-adipogenic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8740	COH-SR4	COH-SR4 (Mitochondria uncoupler SR4)	Others , AMPK
	COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proli...		Others , AMPK
T3739	2,6-Dimethoxyquinone	2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone	Others
	2,6-Dimethoxyquinone (2,6-Dimethoxy-p-benzoquinone) is a member of the class of compounds known as P-benzoquinones. 2,6-Dimethoxyquinone is slightly soluble (in water) and an extremely weak basic (essentially neutral) co...		Others
T4S1173	Agrimol B		Sirtuin , PPAR
	1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.		Sirtuin , PPAR
T2882	Genistin	Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside	Apoptosis , Estrogen Receptor/ERR , Others
	Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-inflammatory and anticancer activities		Apoptosis , Estrogen Receptor/ERR , Others
TN1836	Kudinoside D		LDL , AMPK , PPAR
	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.		LDL , AMPK , PPAR
TN1803	Isoscoparin		Antioxidant , TNF , NO Synthase , Fatty Acid Synthase
	Isoscoparin is derived from Gentiana algida Pall with antioxidant and anti-adipogenic activities. Isoscoparin can be used in stuides about the prevention and treatment of obesity.		Antioxidant , TNF , NO Synthase , Fatty Acid Synthase
TN1189	13-Methylberberine chloride	13-Methylberberine	Others
	13-Methylberberine chloride shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug		Others
T8184	Fucosterol		PARP , Endogenous Metabolite , PPAR
	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.		PARP , Endogenous Metabolite , PPAR
T67855	ISX-3		Others
	ISX-3 is a potent pro-osteogenic and anti-adipogenic agent. ISX-3 can increase the expression of PPARγ. ISX-3 can be for the research of osteopenia and osteoporosis.		Others
T2S0410	Euphorbia factor L1	Euphorbiasteroid	Apoptosis , P-gp
	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant...		Apoptosis , P-gp
T5S2361	Epiberberine		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
T13205	Triphala		Others
	Triphala is an Ayurvedic polyherbal formulation. Triphala inhibits NF-κB activation. Triphala exerts antifungal action, and with anti-adipogenic, anti-inflammatory, and antineoplastic activities.		Others
T12828	Salicortin		NF-κB , JNK
	Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity.		NF-κB , JNK
TN2896	3,5-Dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane		Others
	(3R,5R)-3,5-dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptane may have anti-adipogenic activity.		Others
TN4092	Galanolactone		5-HT Receptor
	Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone ex...		5-HT Receptor
TN3366	Ailanthoidol		IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR
	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailan...		IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR
T36471	Ternatin
	Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and become...
TN2641	15-Methoxypinusolidic acid		ERK , IL Receptor , p38 MAPK , Calcium Channel , NOS , NF-κB , COX , JNK , NMDAR , PPAR
	15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation thro...