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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
13-Methylberberine chloride shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 62.00 | |
5 mg | In stock | $ 143.00 | |
10 mg | In stock | $ 210.00 | |
25 mg | In stock | $ 352.00 | |
50 mg | In stock | $ 523.00 | |
100 mg | In stock | $ 757.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 160.00 |
Description | 13-Methylberberine chloride shows anti-adipogenic effect on 3T3-L1 adipocytes, it has potential as an anti-obesity drug |
In vitro | We screened 11 protoberberine and 2 benzophenanthridine alkaloids for their anti-adipogenic effects on 3T3-L1 adipocytes and found that 13-Methylberberine exhibited the most potent activity. 13-Methylberberine down-regulated the expression of the main adipocyte differentiation transcription factors, peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT enhancer binding protein alpha (C/EBPα±), as well as their target genes. PPARγ, C/EBPα±, and sterol regulatory element binding protein 1 (SREBP-1) protein levels were reduced, and this lipid-reducing effect was attenuated by an AMP-activated protein kinase (AMPK) inhibitor, indicating that the effect of this compound requires the AMPK signaling pathway. Decreased Akt phosphorylation suggested reduced de novo lipid synthesis. C-13 methyl substitution of berberine increased its accumulation in treated cells, suggesting that 13-Methylberberine has improved absorption and higher accumulation compared to berberine. |
Source |
Synonyms | 13-Methylberberine |
Molecular Weight | 385.84 |
Formula | C21H20ClNO4 |
CAS No. | 54260-72-9 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (25.92 mM)
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13-Methylberberine chloride 54260-72-9 Others inhibit Inhibitor 13 Methylberberine chloride 13-Methylberberine Chloride 13-Methylberberine 13Methylberberine chloride Interleukin Related 13-Methylberberinium inhibitor