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COH-SR4

Catalog No. T8740 CAS 73439-19-7

Synonyms: COH-SR4 (Mitochondria uncoupler SR4)

SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proliferation of hepg2 hepatocarcinoma cells

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COH-SR4, CAS 73439-19-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 42.00
50 mg	In stock	$ 58.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.67%

Biological Description

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Description

In vivo

SR4 is a novel mitochondrial uncoupler with anti-obesity and anti-diabetic properties.?SR4 increased oxygen consumption, dissipated mitochondrial membrane potential, induced mitochondrial swelling, and decreased intracellular ATP in cultured cells and isolated liver mitochondria.?Oral feeding of SR4 significantly reduced body weight gain, improved glycemic control and insulin resistance, and prevented dyslipidemia in both high-fat-diet (HFD) induced obese and diabetic db/db mice.?SR4 treatment also decreased liver triglycerides and prevented hepatic steatosis in both animal models.?Mitochondrial uncoupling of SR4 results to activation of AMP-activated protein kinase (AMPK), leading to the phosphorylation and inhibition of acetyl-CoA carboxylase (ACC).?Gene analyses by RT-PCR showed SR4 significantly suppressed the mRNA expression of several lipogenic genes and gluconeogenic genes in the liver of HFD obese mice.?RNA sequencing analysis showed that 642 genes were differentially expressed in liver of db/db mice after SR4 treatment (217 upregulated, 425 down-regulated).?Gene ontology analysis by DAVID indicated SR4 upregulated amino acid metabolism and down-regulated lipid and fatty acid synthesis and glucose metabolism.?These studies demonstrate that SR4 may be a promising compound for treatment of T2DM and obesity

Synonyms	COH-SR4 (Mitochondria uncoupler SR4)
Molecular Weight	350.02
Formula	C13H8Cl4N2O
CAS No.	73439-19-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 4 mg/mL (11.43 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sharad S Singhal, James L Figarola, Jyotsana Singhal,et al.COH-SR4, a Novel Mitochondrial Uncoupler, Improves Metabolic Alterations in Obese and Diabetic Mice.

Related compound libraries

This product is contained In the following compound libraries：

Mitochondria-Targeted Compound Library Antioxidant Compound Library AMPK-Targeted Compound Library PI3K-AKT-mTOR Compound Library Reprogramming Compound Library Bioactive Compound Library Oxidation-Reduction Compound Library Anti-Prostate Cancer Compound Library Metabolism Compound Library Anti-Cancer Compound Library

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Related compounds with same targets

AMPK activator 4 DK419 Kazinol B 4-Hydroxycinnamamide Shizukaol D 3α-Hydroxymogrol HL271 XMD-17-51

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

COH-SR4 73439-19-7 Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling AMPK anticancer anti-proliferative kinase COH-SR4 (Mitochondria uncoupler SR4) leukemia protein breast cancers lung COH SR4 COHSR4 anti-adipogenic COH-SR-4 Inhibitor melanoma inhibit AMP-activated protein kinase AMP-activated inhibitor

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