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COH-SR4

Catalog No. T8740 CAS 73439-19-7

Synonyms: COH-SR4 (Mitochondria uncoupler SR4)

COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proliferation of hepg2 hepatocarcinoma cells

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COH-SR4, CAS 73439-19-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 42.00
50 mg	In stock	$ 58.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.67%

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Description

In vivo

SR4 is a novel mitochondrial uncoupler with anti-obesity and anti-diabetic properties.?SR4 increased oxygen consumption, dissipated mitochondrial membrane potential, induced mitochondrial swelling, and decreased intracellular ATP in cultured cells and isolated liver mitochondria.?Oral feeding of SR4 significantly reduced body weight gain, improved glycemic control and insulin resistance, and prevented dyslipidemia in both high-fat-diet (HFD) induced obese and diabetic db/db mice.?SR4 treatment also decreased liver triglycerides and prevented hepatic steatosis in both animal models.?Mitochondrial uncoupling of SR4 results to activation of AMP-activated protein kinase (AMPK), leading to the phosphorylation and inhibition of acetyl-CoA carboxylase (ACC).?Gene analyses by RT-PCR showed SR4 significantly suppressed the mRNA expression of several lipogenic genes and gluconeogenic genes in the liver of HFD obese mice.?RNA sequencing analysis showed that 642 genes were differentially expressed in liver of db/db mice after SR4 treatment (217 upregulated, 425 down-regulated).?Gene ontology analysis by DAVID indicated SR4 upregulated amino acid metabolism and down-regulated lipid and fatty acid synthesis and glucose metabolism.?These studies demonstrate that SR4 may be a promising compound for treatment of T2DM and obesity

Synonyms	COH-SR4 (Mitochondria uncoupler SR4)
Molecular Weight	350.03
Formula	C13H8Cl4N2O
CAS No.	73439-19-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4 mg/mL (11.43 mM)

References and Literature

1. Sharad S Singhal, James L Figarola, Jyotsana Singhal,et al.COH-SR4, a Novel Mitochondrial Uncoupler, Improves Metabolic Alterations in Obese and Diabetic Mice.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library PI3K-AKT-mTOR Compound Library Glycolysis Compound Library Oxidation-Reduction Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library Hematonosis Compound Library Anti-Aging Compound Library Covalent Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

COH-SR4 73439-19-7 Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling AMPK anticancer anti-proliferative kinase leukemia protein breast COH-SR4 (Mitochondria uncoupler SR4) cancers lung COH SR4 COHSR4 anti-adipogenic COH-SR-4 Inhibitor melanoma inhibit AMP-activated protein kinase Mitochondria uncoupler SR4 AMP-activated inhibitor

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