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Fucosterol

Catalog No. T8184 CAS 17605-67-3

Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.

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Fucosterol, CAS 17605-67-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
5 mg	In stock	$ 87.00
10 mg	In stock	$ 148.00
25 mg	In stock	$ 253.00
50 mg	In stock	$ 377.00
100 mg	In stock	$ 535.00

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Purity: 99.68%

Purity: 98.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.
In vitro	Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes [1]. Fucosterol shows cytotoxicity against T47D and HT29 cell lines (IC50s: 27.94 and 70.41 μg/ml) [3]. Fucosterol decreases the proliferation of HEK293, MCF-7, and SiHa cells (IC50s: 185.4, 43.3, and 34.0 μg/ml) [4].
In vivo	Fucosterol (p.o.; 30mg/kg) causes a significant decrease in serum glucose concentrations and exhibits inhibition of sorbitol accumulations in the lenses [2].
Cell Research	Cell Line: 3T3-L1 adipocytes. Concentration: 0 μM; 25 μM; 50 μM. Incubation Time: 7 days [1]
Source	Natural Products > Alariaceae > Undaria

Molecular Weight	412.69
Formula	C29H48O
CAS No.	17605-67-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 16.67 mg/mL (4.39 mM)

References and Literature

1. Jung HA, et al. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 2014 Jun;37(6):713-20. 2. Lee YS, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch Pharm Res. 2004 Nov;27(11):1120-2. 3. Khanavi M, et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn Mag. 2012 Jan;8(29):60-4. 4. Caamal-Fuentes E, et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata. Pharm Biol. 2014 Oct;52(10):1244-8.

Related compound libraries

This product is contained In the following compound libraries：

Marine Natural Product Library Anti-Cancer Active Compound Library Tobacco Monomer Library Chinese Pharmacopoeia Natural Product Library Anti-Diabetic Compound Library Anti-Ovarian Cancer Compound Library Glycometabolism Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Antioxidant Compound Library Anti-Breast Cancer Compound Library

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Keywords

Fucosterol 17605-67-3 Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism PPAR PARP Endogenous Metabolite poly ADP ribose polymerase Inhibitor inhibit inhibitor

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