Home Tools
Log in
Cart

Search Result

Search Results for " adc "

Targets

739

Compounds

13

Natural Products

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T20023 ADC-13 ADC 13 Others
ADC-13 is a bioactive chemical agent.
T29647 ADC-02390946
ADC-02390946 is a bioactive chemical.
T11249L Dxd Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ Topoisomerase
Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.
T74178 Glembatumumab vedotin CR011-vcMMAE,CR 011 ADC,CDX-011 Microtubule Associated
Glembatumumab vedotin (CDX-011) is an antibody-activated small molecule coupling, Glembatumumab vedotin has potent anticancer effects and can be used in the study of triple negative breast cancer (TNBC).
T38889 Thailanstatin A
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s...
T14348 Auristatin E Microtubule Associated
Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an...
T15175 DSP Crosslinker Others
DSP Crosslinker is a cleavable ADC linker, used in antibody-drug conjugates (ADCs) synthesis[1].
T15171 DSG Crosslinker Others
DSG Crosslinker is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
T14349 Auristatin F Microtubule Associated
Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.
T15058 DBCO-amine
DBCO-amine is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis[1].
T22334 FMOC-3VVD-OH Others
FMOC-3VVD-OH is an active chemical.
T15141 DM4 Ravtansine Others , Microtubule Associated
DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.
T15098 Deruxtecan Others
Deruxtecan is an ADC drug-linker conjugate consisting of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker for the synthesis of DS-8201 and U3-1402.
T1992 Mertansine DM1,Maytansinoid DM1 Microtubule Associated
Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4...
T17389 AMAS Others
AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing molecules.
T11120 Duocarmycin TM DNA Alkylation , Antibiotic
Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
T4346 SPDB Others
SPDB is a small fragment linked to DM4 conjugates. It conjugates to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.
T3256 MMAF MonoMethyl auristatin F Others , Microtubule Associated
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
T12081 MMAF-OMe Monomethyl auristatin F methyl ester
MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji ...
T17950 Fmoc-Asp-NH2 Others
Fmoc-Asp-NH2 is a cleavable ADC linker. Fmoc-Asp-NH2 can be used in the synthesis of antibody-drug conjugates (ADCs).
T16218 N-Boc-PEG5-bromide Others , PROTAC Linker
N-Boc-PEG5-bromide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
T8003 Methotrexate disodium Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
T18723 Succinic anhydride Others
Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.
T16557 PNU-159682 Topoisomerase
PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin.
T15976 Mal-PEG1-NHS ester Others , PROTAC Linker
Mal-PEG1-NHS ester is a cleavable and PEG-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It also is PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
T15179 DTSSP Crosslinker Others
DTSSP Crosslinker is a cleavable ADC linker and can be used to synthesize antibody-drug conjugates (ADCs).
T15176 DSS Crosslinker Others
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters a...
T6897 Monomethyl auristatin E Vedotin,MMAE Apoptosis , Microtubule Associated
Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.
T21408 DM1-SMe DM1-SSMe Microtubule Associated
DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell ...
T22278 BOC-Dap-NE Others
Boc-Dap-NE used in the synthesis of antibody-drug conjugates (ADCs).It is a cleavable ADC linker
T14858 Calicheamicin Calicheamicin γ1 Others
Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.
T18479 NH-bis(C1-Boc) Others
NH-bis(C1-Boc)is a uncleavable linker. NH-bis can be used for antibody-drug conjugates (ADC).
T8924 MFCD28987368 Others
MFCD28987368 is a degradable ADC linker that can be used in the synthesis of antibody coupled drugs (ADCs).
T18867 Val-Cit-PAB-MMAE
Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE . MMAE a potent mitotic inhibitor by inhibiting tubulin polymerizat...
T18868 Val-Cit Others
Val-Cit is a cleavable ADC linker. Val-Cit is used in the synthesis of antibody-drug conjugates (ADCs).
T17691 Boc-Val-Cit-OH Others
Boc-Val-Cit-OH is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
T17372 Ald-Ph-NHS ester Others
Ald-Ph-NHS ester is a non-cleavable linker used in antibody-drug-conjugation (ADC).
T17213 Val-cit-PAB-OH Others
Val-cit-PAB-OH is an ADC linker that is cleavable.
T17693 Boc-Val-Cit-PAB Others
Boc-Val-Cit-PAB is a cleavable ADC linker. Boc-Val-Cit-PAB used in the synthesis of antibody-drug conjugates (ADCs).
T17952 Fmoc-Gly-Gly-OH Others
Fmoc-Gly-Gly-OH is a cleavable ADC linker. Fmoc-Gly-Gly-OH can be used in the synthesis of antibody-drug conjugates (ADCs).
T6741 SPDP SPDP Crosslinker Others
SPDP is a short-chain crosslinker, which is used for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. SPDP could ...
T7767 FMoc-Val-Cit-PAB-PNP Others
Fmoc-Val-Cit-PAB-PNP is a linker for Antibody-Drug-Conjugation (ADC).
T17953 Fmoc-Gly-Gly-Phe-OtBu Others
Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker. Fmoc-Gly-Gly-Phe-OtBu can be used in the synthesis of antibody-drug conjugates (ADCs).
T18321 Mc-Val-Cit-PAB-Cl Others
Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC5...
T18143 M-PEG12-OH Dodecaethylene Glycol Monomethyl Ether Others , PROTAC Linker
m-PEG12-OH (Dodecaethylene Glycol Monomethyl Ether) is a PEG-based PROTAC linker. m-PEG12-OH can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of ant...
T18540 Phe-Lys(Trt)-PAB Others
Phe-Lys(Trt)-PAB is a cathepsin-cleavable linker utilized in the development of antibody-drug conjugates (ADCs)[1], serving as a crucial component for facilitating the release of therapeutic agents within targeted cells.
T4678 Fmoc-Val-Cit-PAB Others
Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).
T18308 MC-Gly-Gly-Phe
MC-Gly-Gly-Phe is a cleavable linker. MC-Gly-Gly-Phe can be used for antibody-drug conjugates (ADC).
T16225 N-Hydroxysulfosuccinimide sodium
N-Hydroxysulfosuccinimide sodium is a non-cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
T17983 Fmoc-Val-Cit-PAB-MMAE Others
Fmoc-Val-Cit-PAB-MMAE is consisted of the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). Fmoc-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC.

Compounds

ADC-13
T20023
Synonym: ADC 13
Target: Others
ADC-02390946
T29647
Synonym:
Target:
Dxd
T11249L
Synonym: Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ
Target: Topoisomerase
Glembatumumab vedotin
T74178
Synonym: CR011-vcMMAE,CR 011 ADC,CDX-011
Target: Microtubule Associated
Thailanstatin A
T38889
Synonym:
Target:
Auristatin E
T14348
Synonym:
Target: Microtubule Associated
DSP Crosslinker
T15175
Synonym:
Target: Others
DSG Crosslinker
T15171
Synonym:
Target: Others
Auristatin F
T14349
Synonym:
Target: Microtubule Associated
DBCO-amine
T15058
Synonym:
Target:
FMOC-3VVD-OH
T22334
Synonym:
Target: Others
DM4
T15141
Synonym: Ravtansine
Target: Others, Microtubule Associated
Deruxtecan
T15098
Synonym:
Target: Others
Mertansine
T1992
Synonym: DM1,Maytansinoid DM1
Target: Microtubule Associated
AMAS
T17389
Synonym:
Target: Others
Duocarmycin TM
T11120
Synonym:
Target: DNA Alkylation, Antibiotic
SPDB
T4346
Synonym:
Target: Others
MMAF
T3256
Synonym: MonoMethyl auristatin F
Target: Others, Microtubule Associated
MMAF-OMe
T12081
Synonym: Monomethyl auristatin F methyl ester
Target:
Fmoc-Asp-NH2
T17950
Synonym:
Target: Others
N-Boc-PEG5-bromide
T16218
Synonym:
Target: Others, PROTAC Linker
Methotrexate disodium
T8003
Synonym:
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate
Succinic anhydride
T18723
Synonym:
Target: Others
PNU-159682
T16557
Synonym:
Target: Topoisomerase
Mal-PEG1-NHS ester
T15976
Synonym:
Target: Others, PROTAC Linker
DTSSP Crosslinker
T15179
Synonym:
Target: Others
DSS Crosslinker
T15176
Synonym:
Target: Others
Monomethyl auristatin E
T6897
Synonym: Vedotin,MMAE
Target: Apoptosis, Microtubule Associated
DM1-SMe
T21408
Synonym: DM1-SSMe
Target: Microtubule Associated
BOC-Dap-NE
T22278
Synonym:
Target: Others
Calicheamicin
T14858
Synonym: Calicheamicin γ1
Target: Others
NH-bis(C1-Boc)
T18479
Synonym:
Target: Others
MFCD28987368
T8924
Synonym:
Target: Others
Val-Cit-PAB-MMAE
T18867
Synonym:
Target:
Val-Cit
T18868
Synonym:
Target: Others
Boc-Val-Cit-OH
T17691
Synonym:
Target: Others
Ald-Ph-NHS ester
T17372
Synonym:
Target: Others
Val-cit-PAB-OH
T17213
Synonym:
Target: Others
Boc-Val-Cit-PAB
T17693
Synonym:
Target: Others
Fmoc-Gly-Gly-OH
T17952
Synonym:
Target: Others
SPDP
T6741
Synonym: SPDP Crosslinker
Target: Others
FMoc-Val-Cit-PAB-PNP
T7767
Synonym:
Target: Others
Fmoc-Gly-Gly-Phe-OtBu
T17953
Synonym:
Target: Others
Mc-Val-Cit-PAB-Cl
T18321
Synonym:
Target: Others
m-PEG12-OH
T18143
Synonym: Dodecaethylene Glycol Monomethyl Ether
Target: Others, PROTAC Linker
Phe-Lys(Trt)-PAB
T18540
Synonym:
Target: Others
Fmoc-Val-Cit-PAB
T4678
Synonym:
Target: Others
MC-Gly-Gly-Phe
T18308
Synonym:
Target:
N-Hydroxysulfosuccinimide sodium
T16225
Synonym:
Target:
Fmoc-Val-Cit-PAB-MMAE
T17983
Synonym:
Target: Others
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Cat No. Product Name Synonyms Targets
T0968 Paclitaxel Taxol,NSC 125973 Apoptosis , Microtubule Associated , Autophagy
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
T16016 Maytansinol Ansamitocin P-0 Apoptosis , Microtubule Associated
Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.
T9784 Docosanedioic acid  PROTAC Linker
BEHENIC ACID is a alkyl-chain-based PROTAC linker. BEHENIC ACID is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
T1123 Camptothecin NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal
Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
TP1180 Dolastatin 10 NSC 376128,DLS 10 Microtubule Associated
Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization.
T1703 SN-38 NK012,SN 38 DNA/RNA Synthesis , Topoisomerase , Autophagy
SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 has antitumor activity and induces autophagy.
T4820 Maleimide 2,5-Pyrroledione Others
Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its b...
T1020 Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,NSC 123127 Apoptosis , Mitophagy , HBV , HIV Protease , Topoisomerase , Antibacterial , Antibiotic , AMPK , Autophagy
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitum...
T5749 10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,10-Deacetylpaclitaxel 7-Xyloside Others , Microtubule Associated
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.
T1511 Daunorubicin hydrochloride Daunomycin HCl,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin Apoptosis , DNA/RNA Synthesis , Topoisomerase , Antibacterial , Antibiotic , Autophagy
Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein synthesis.
T1456 Doxorubicin Hydroxydaunorubicin,Adriamycin Topoisomerase , AMPK
Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.
T73915 Luisol A
Luisol A, an aromatic tetraol and anthraquinone antibiotic analog, serves as a significant metabolite produced by an estuarine marine actinomycete from the genus Streptomyces. Additionally, it functions as an ADC (Antibo...
T39562 γ-Amanitin
γ-Amanitin, an ADC (antibody-drug conjugate) cytotoxin isolated from mushrooms, inhibits RNA polymerase II, disrupting mRNA synthesis. It exhibits effects akin to those of α-Amanitin and β-Amanitin.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00404 Acetoacetate decarboxylase Protein, Clostridium acetobutylicum, Recombinant (His) Clostridium acetobutylicum Baculovirus Insect Cells
Catalyzes the conversion of acetoacetate to acetone and carbon dioxide. Acetoacetate decarboxylase Protein, Clostridium acetobutylicum, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The pre...
TMPK-00964 MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of...
TMPJ-01298 PRADC1 Protein, Human, Recombinant (His) Human HEK293 Cells
PRADC1, also known as C2orf7 or PAP21, is short for Protease-associated domain-containing protein 1. It is a 188 aa. with a 21 aa. signal, and the 171 located Asn can be glycosylated. PRADC1 has two mutagenesis which are...
TMPJ-01152 MAdCAM-1 Protein, Human, Recombinant (His) Human HEK293 Cells
MAdCAM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-65 KDa and the accession number is Q4PKD0.
TMPJ-01150 MAdCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated Human HEK293 Cells
MAdCAM-1 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 55-80 KDa and the accession number is Q4PKD0.
TMPJ-01151 MAdCAM-1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
MAdCAM-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 75-100 KDa and the accession number is Q4PKD0.
TMPK-00965 MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc) Human HEK293 Cells
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of...
TMPK-00966 MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His) Human HEK293 Cells
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of...
TMPK-01031 MAdCAM-1 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of...
TMPY-02648 PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc) Human HEK293 Cells
Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons. This modulation of excitability is mediate...
TargetMol