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Succinic anhydride

Name: Succinic anhydride
Brand: TargetMol
SKU: T18723
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T18723Cas No. 108-30-5

Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.

Succinic anhydride

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Purity: 98.53%

Catalog No. T18723Cas No. 108-30-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.53%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Succinic anhydride AI Summary

Succinic anhydride exhibits multiple bioactivities: it acts as an agonist of the Thyroid Stimulating Hormone Receptor with a potency of 1258.9 nM, leading to the activation of intracellular cAMP concentrations. It also functions as an agonist of glucocorticoid receptor signaling, showing a potency of 63.1 nM. Additionally, Succinic anhydride serves as a delayed death inhibitor of the malarial parasite plastid, with potencies of 18526.0 nM after a 96-hour incubation and 2332.3 nM after a 48-hour incubation. Moreover, it induces DNA re-replication in MCF 10a normal breast cells at 1458.1 nM and in SW480 colon adenocarcinoma cells at 25.9 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	100.07
Formula	C₄H₄O₃
Cas No.	108-30-5
Smiles	O=C1CCC(=O)O1
Relative Density.	1.572 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (999.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (39.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.9930 mL	49.9650 mL	99.9300 mL	499.6502 mL
5 mM	1.9986 mL	9.9930 mL	19.9860 mL	99.9300 mL
10 mM	0.9993 mL	4.9965 mL	9.9930 mL	49.9650 mL
20 mM	0.4997 mL	2.4983 mL	4.9965 mL	24.9825 mL
50 mM	0.1999 mL	0.9993 mL	1.9986 mL	9.9930 mL
100 mM	0.0999 mL	0.4997 mL	0.9993 mL	4.9965 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc