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DSS Crosslinker

🥰Excellent
Catalog No. T15176Cas No. 68528-80-3

DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.

DSS Crosslinker

DSS Crosslinker

🥰Excellent
Purity: 99.72%
Catalog No. T15176Cas No. 68528-80-3
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.
Pack SizePriceAvailabilityQuantity
100 mg$41In Stock
500 mg$57In Stock
1 g$74In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:99.72%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is a homobifunctional crosslinker that is cell membrane permeable, with amine-reactive NHS esters at both ends of an 8-atom [11.4 angstrom] spacer arm for conjugating proteins, including intracellular proteins.
In vitro
ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.
Chemical Properties
Molecular Weight368.34
FormulaC16H20N2O8
Cas No.68528-80-3
SmilesO(C(CCCCCCC(ON1C(=O)CCC1=O)=O)=O)N2C(=O)CCC2=O
Relative Density.1.4 g/cm3
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 47 mg/mL (127.6 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.43 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7149 mL13.5744 mL27.1488 mL135.7441 mL
5 mM0.5430 mL2.7149 mL5.4298 mL27.1488 mL
10 mM0.2715 mL1.3574 mL2.7149 mL13.5744 mL
20 mM0.1357 mL0.6787 mL1.3574 mL6.7872 mL
50 mM0.0543 mL0.2715 mL0.5430 mL2.7149 mL
100 mM0.0271 mL0.1357 mL0.2715 mL1.3574 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Non-cleavableInhibitorinhibitDSS CrosslinkerAntibody-drug conjugates linkersADCLinkerADC LinkersADC Linker
Related Tags: buy DSS Crosslinker | purchase DSS Crosslinker | DSS Crosslinker cost | order DSS Crosslinker | DSS Crosslinker chemical structure | DSS Crosslinker in vitro | DSS Crosslinker formula | DSS Crosslinker molecular weight
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