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Fmoc-Val-Cit-PAB

Catalog No. T4678 CAS 159858-22-7

Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).

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Fmoc-Val-Cit-PAB, CAS 159858-22-7

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25 mg	In stock	$ 29.00

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Purity: 97.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).

Molecular Weight	601.69
Formula	C33H39N5O6
CAS No.	159858-22-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 123.75 mg/mL (205.67 mM)

References and Literature

1. Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc42020050k. Epub 2013 May 3. Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc42020050k. Epub 2013 May 3. 2. Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7). 3. Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6. 4. Kanazaki K, Sano K, Makino A, Yamauchi F, Takahashi A, Homma T, Ono M, Saji H. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. doi:10.12016/j.jconrel.2016.02.2017. Epub 2016 Feb 8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-COVID-19 Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fmoc-Val-Cit-PAB 159858-22-7 Others inhibit Antibody-drug conjugates linkers ADC Linkers FmocValCitPAB Inhibitor Fmoc Val Cit PAB inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.