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Deruxtecan

Catalog No. T15098   CAS 1599440-13-7

Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

Deruxtecan, CAS 1599440-13-7
Pack Size Availability Price/USD Quantity
1 mg In stock 393.00
5 mg In stock 897.00
10 mg In stock 1743.00
25 mg In stock 3142.00
1 mL * 10 mM (in DMSO) In stock 2771.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.
Targets&IC50 Camptothecins
In vitro Antibody-drug conjugates deliver anticancer agents selectively and efficiently to tumor tissue and have significant antitumor efficacy with a wide therapeutic window[2].
Molecular Weight 1034.05
Formula C52H56FN9O13
CAS No. 1599440-13-7

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 34 mg/mL (32.88 mM)

H2O: < 0.1 mg/mL (insoluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. NOGUCHI, Shigeru, et al. METHOD FOR SELECTIVELY MANUFACTURING ANTIBODY-DRUG CONJUGATE. WO2017002776A1. 2. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.

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