mdr1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1651	Furanodiene		Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T3S0012	Coniferyl ferulate		P-gp , GST
	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...		P-gp , GST
T2S0223	Isosinensetin	6-Demethoxynobiletin	Antioxidant , HIV Protease , Antibacterial , P-gp
	1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.		Antioxidant , HIV Protease , Antibacterial , P-gp
T8426	Encequidar	HM30181,HM30181A	P-gp
	Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.		P-gp
TN4761	Phellamurin		P-gp
	Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini...		P-gp
T12341	P-gp inhibitor 1		Others , P-gp
	P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).		Others , P-gp
TJS1159	Chrysosplenetin	Chrysosptertin B	P450 , Ferroptosis , P-gp
	Chrysosplenetin is a metabolic inhibitor of artemisinin.		P450 , Ferroptosis , P-gp
T2S0271	Voacamine	Voacanginine	Cannabinoid Receptor , P-gp
	Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini...		Cannabinoid Receptor , P-gp
T16561	Polyoxyethylene stearate	POES	Antibacterial , P-gp
	Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.		Antibacterial , P-gp
T3002	Piperine	1-Piperoylpiperidine,Bioperine	P450 , Endogenous Metabolite , P-gp , Autophagy
	Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.		P450 , Endogenous Metabolite , P-gp , Autophagy
T11071	Dofequidar fumarate	MS-209	P-gp
	Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass...		P-gp
T6287	Tariquidar	XR9576	P-gp
	Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.		P-gp
T0351	Risperidone	Risperidal,R 64 766	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , P-gp
	Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T4059	Selamectin	UK-124114	Chloride channel , P-gp , Parasite
	Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel...		Chloride channel , P-gp , Parasite
T4034	Solamargine	Solamargin,δ-Solanigrine	Apoptosis , p38 MAPK , P-gp , STAT
	Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel...		Apoptosis , p38 MAPK , P-gp , STAT
T13383	Zamicastat	BIA 5-1058	BCRP , Hydroxylase , P-gp
	Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively).		BCRP , Hydroxylase , P-gp
T3392	Sinapine thiocyanate		P-gp , AChE
	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...		P-gp , AChE
T8389	Trifluoperazine	trifluoroperazine	CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy
	Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
T11578L	Encequidar mesylate	HM30181 mesylate,HM30181A mesylate	P-gp
	Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.		P-gp