inflammasome — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3230	NLRP3-IN-2	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR) , NOD
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i...		NOD-like Receptor (NLR) , NOD
T15052	Dapansutrile		NOD-like Receptor (NLR) , NOD
	Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.		NOD-like Receptor (NLR) , NOD
T8828	CP 424174		IL Receptor
	CP 424174 is an inhibitor of IL-1β post-translational processing with IC50 of 210 nM. Inhibits the formation of mature IL-1β. Indirectly inhibits NLRP3. Active in vivo and orally bioavailable.		IL Receptor
T9222	Emlenoflast	MCC7840	NOD-like Receptor (NLR) , NOD
	Emlenoflast (MCC7840) is a selective inhibitor of NLRP3 inflammasome.		NOD-like Receptor (NLR) , NOD
TQ0165	Arglabin	(+)-Arglabin	NOD-like Receptor (NLR) , Transferase , NOD , Autophagy
	Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.		NOD-like Receptor (NLR) , Transferase , NOD , Autophagy
T0948	Adrenalone hydrochloride	Adrenalone HCl	Adrenergic Receptor
	Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a loc...		Adrenergic Receptor
T1902	BAY 11-7082	BAY 11-7821	Apoptosis , Others , IκB/IKK , DUB , Autophagy
	BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM).		Apoptosis , Others , IκB/IKK , DUB , Autophagy
T20089	ATP	Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate	Endogenous Metabolite
	ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specifi...		Endogenous Metabolite
T9352	Hydrocotarnine		Others
	hydrocotarnine is an inhibitor of Cbl.		Others
T28178	NLRP3-IN-9	INF-4E,INF 4E,INF4E	NOD
	NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ...		NOD
T2893	Muscone	3-Methylcyclopentadecanone,Methylexaltone	MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin
	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T1404	Stavudine	d4T,Sanilvudine,BMY-27857,NSC 163661	Apoptosis , Nucleoside Antimetabolite/Analog , HIV Protease , NOD-like Receptor (NLR) , Reverse Transcriptase , Autophagy
	Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
T0342	Carvedilol phosphate hemihydrate	Carvedilol phosphate,BM 14190 (phosphate hemihydrate)	VEGFR , Others , Potassium Channel , LDL , Integrin , Gap Junction Protein , NADPH , Adrenergic Receptor , Autophagy
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathom...
T2812	ATP disodium salt hydrate	ATP disodium,ATP disodium salt,Adenosine disodium triphosphate	Others , Endogenous Metabolite
	ATP disodium salt hydrate (Adenosine disodium triphosphate) is a nucleoside triphosphate used in cells as a coenzyme often called the "molecular unit of currency" of intracellular energy transfer.		Others , Endogenous Metabolite
T20731	Brilliant blue G-250	BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G	P2X Receptor
	Brilliant blue G-250 (Acid blue 90, Coomassie Brilliant Blue G) is an antagonist of the P2X7 purinergic receptor.		P2X Receptor
T1352	ATP disodium salt	Adenosine 5'-triphosphate disodium salt,ATP,ATP disodium,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate	P2X Receptor , Endogenous Metabolite
	ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist.		P2X Receptor , Endogenous Metabolite
T28281	OXSI-2	OXSI 2,Syk Inhibitor	Syk
	OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets.		Syk
T25548	JC124	JC 124,JC-124	NOD
	JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.		NOD
T6S1367	Procyanidin B2	Proanthocyanidin B2	Reactive Oxygen Species , NOD
	Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ...		Reactive Oxygen Species , NOD
T8553	BC-1471		Others
	BC-1471 is a STAM-binding protein (STAMBP) deubiquitinase inhibitor. BC-1471 inhibits inflammasome activity of NALP7 (NACHT, LRR and PYD domains-containing protein 7) [1].		Others