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Emlenoflast

Catalog No. T9222 CAS 1995067-59-8

Synonyms: MCC7840

Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.

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Emlenoflast, CAS 1995067-59-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Emlenoflast is a potent and selective inhibitor of NLRP3 inflammasome.
Targets&IC50	NLRP3:< 100 nM

Synonyms	MCC7840
Molecular Weight	388.49
Formula	C19H24N4O3S
CAS No.	1995067-59-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533. 2. O'neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.

Related Products

Related compounds with same targets

Emlenoflast Asymmetric dimethylarginine 6-Biopterin NLRP3-IN-10 L-Canavanine sulfate CY-09 MCC950 Imperatorin

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Emlenoflast 1995067-59-8 NF-Kb信号通路免疫与炎症 NOD NOD-like Receptor (NLR) MCC7840 MCC 7840 sulfonylurea NLRP3 inhibit MCC-7840 inflammatory inflammasome Inhibitor inhibitor

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