Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
Description | Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects. |
In vitro | Arglabin-stimulated macrophages displayed a strong cytotoxic activity and the lowest doses (1.25 μg/mL and 0.125 μg/mL) induced a significant stimulation of cell mitochondrial metabolism, which correlated with [3H]TdR uptake by J774.1 cells under the same experimental conditions. Arglabin triggered the production of the three cytokines from J774-1 cells [1]. Arglabin exhibits anti exudative and antiproliferative properties on the models of acute aseptic inflammation caused by formalin, carrageenan, and histamine, and on the model of proliferative inflammation accompanying cotton-pellet granuloma [2]. Arglabin is able to reduce the proportion of AML stem cells (CD34+CD38-) in primary AML cells [3]. |
Synonyms | 阿格拉宾, (+)-Arglabin |
Molecular Weight | 246.3 |
Formula | C15H18O3 |
CAS No. | 84692-91-1 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 95 mg/mL (385.7 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Arglabin 84692-91-1 NF-Kb信号通路 代谢 免疫与炎症 自噬 Autophagy NOD NOD-like Receptor (NLR) Transferase (+)-Arglabin inflammasome Ftase anti-inflammatory Farnesyl Transferase antitumor RAS Inhibitor proto-oncogene inhibit inhibitor