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Arglabin

Catalog No. TQ0165 CAS 84692-91-1

Synonyms: 阿格拉宾, (+)-Arglabin

Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.

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Arglabin, CAS 84692-91-1

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description

Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.

In vitro

Arglabin-stimulated macrophages displayed a strong cytotoxic activity and the lowest doses (1.25 μg/mL and 0.125 μg/mL) induced a significant stimulation of cell mitochondrial metabolism, which correlated with [3H]TdR uptake by J774.1 cells under the same experimental conditions. Arglabin triggered the production of the three cytokines from J774-1 cells [1]. Arglabin exhibits anti exudative and antiproliferative properties on the models of acute aseptic inflammation caused by formalin, carrageenan, and histamine, and on the model of proliferative inflammation accompanying cotton-pellet granuloma [2]. Arglabin is able to reduce the proportion of AML stem cells (CD34+CD38-) in primary AML cells [3].

Synonyms	阿格拉宾, (+)-Arglabin
Molecular Weight	246.3
Formula	C15H18O3
CAS No.	84692-91-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 95 mg/mL (385.7 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bottex-Gauthier C, et al. In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall. (Asteraceae). Biotechnol Ther. 1993;4(1-2):77-98. 2. Abil'daeva AZh, et al. Anti-inflammatory effect of arglabin and 11,13-dihydro-13-dimethylaminoarglabin hydrochloride. Eksp Klin Farmakol. 2004 Jan-Feb;67(1):37-9. 3. Zhang Q, et al. Guaianolide sesquiterpene lactones, a source to discover agents that selectively inhibit acute myelogenous leukemia stem and progenitor cells. J Med Chem. 2012 Oct 25;55(20):8757-69.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Terpene Natural Product Library Inhibitor Library Anti-Tumor Natural Product Library Immunology/Inflammation Compound Library Covalent Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Rare Natural Compound Library

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Keywords

Arglabin 84692-91-1 NF-Kb信号通路代谢免疫与炎症自噬 Autophagy NOD NOD-like Receptor (NLR) Transferase (+)-Arglabin inflammasome Ftase anti-inflammatory Farnesyl Transferase antitumor RAS Inhibitor proto-oncogene inhibit inhibitor

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