Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 397.00 | |
25 mg | In stock | $ 663.00 | |
50 mg | In stock | $ 945.00 | |
100 mg | In stock | $ 1,280.00 | |
500 mg | In stock | $ 2,570.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 272.00 |
Description | JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities. |
In vitro | JC124 selectively inhibits NLRP3 inflammasome formation and activates caspase-1, and reduces IL-1β[1]. |
In vivo | In adult male Sprague-Dawley rats bearing traumatic brain injury, intraperitoneal administration of JC124 (100 mg/kg) reduces the number of injury-induced degenerating neurons, inflammatory cell response, and cortical lesion volume. JC124 decreases the expression of NLRP3, IL-1 beta, TNFα, ASC, iNOS, and caspase-1[1]. |
Synonyms | JC 124, JC-124 |
Molecular Weight | 382.86 |
Formula | C17H19ClN2O4S |
CAS No. | 1638611-48-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (587.7 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.
You can also refer to dose conversion for different animals. More
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JC124 1638611-48-9 Immunology/Inflammation NF-Κb NOD JC 124 JC-124 inhibitor inhibit