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NLRP3-IN-9

Catalog No. T28178 CAS 88039-46-7

Synonyms: INF-4E, INF 4E, INF4E

NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NLRP3-IN-9, CAS 88039-46-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 178.00
25 mg	In stock	$ 397.00
50 mg	In stock	$ 589.00
100 mg	In stock	$ 843.00
500 mg	In stock	$ 1,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	INF-4E, INF 4E, INF4E
Molecular Weight	240.68
Formula	C12H13ClO3
CAS No.	88039-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (249.29 mM)

References and Literature

1. Cocco M, Garella D, Di Stilo A, Borretto E, Stevanato L, Giorgis M, Marini E, Fantozzi R, Miglio G, Bertinaria M. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014 Dec 26;57(24):10366-82. doi: 10.1021/jm501072b. Epub 2014 Dec 4. PubMed PMID: 25418070.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Mitochondria-Targeted Compound Library Pyroptosis Compound Library Immunology/Inflammation Compound Library NF-κB Signaling Compound Library Anti-Prostate Cancer Compound Library Anti-Liver Cancer Compound Library Bioactive Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

GSK717 BMS986299 YQ128 Molsidomine NLRP3-IN-11 Nigericin sodium salt Emlenoflast sodium NLRP3-IN-2

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NLRP3-IN-9 88039-46-7 NF-Κb Immunology/Inflammation NOD inflammasome NOD-like Receptor (NLR) myocardial injury NLRP3 IN 9 caspase-1 dysfunction NLRP3IN9 Inhibitor pyroptosis inhibit NLRP-3-IN-9 INF-4E THP-1 cells INF 4E INF4E inhibitor

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