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NLRP3-IN-2

Catalog No. T3230 CAS 16673-34-0

Synonyms: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide, NLRP3 Inflammasome Inhibitor I

It is a NLRP3 Inflammasome Inhibitor I.

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NLRP3-IN-2, CAS 16673-34-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

It is a NLRP3 Inflammasome Inhibitor I.

Synonyms	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide, NLRP3 Inflammasome Inhibitor I
Molecular Weight	368.835
Formula	C16H17ClN2O4S
CAS No.	16673-34-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 66 mg/mL(178.9 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Baldwin, A., Brough, D., & Freeman, S. (2015). Inhibiting the Inflammasome: A Chemical Perspective. Journal Of Medicinal Chemistry, 59(5), 1691-1710. doi: 10.1021/acs.jmedchem.5b01091 2. Marchetti, C., Chojnacki, J., Toldo, S., Mezzaroma, E., Tranchida, N., & Rose, S. et al. (2014). A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse. Journal Of Cardiovascular Pharmacology, 63(4), 316-322. doi: 10.1097/fjc.202002020020200200020053

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NLRP3-IN-2 16673-34-0 Immunology/Inflammation NF-Κb NOD-like Receptor (NLR) NOD infarction inhibit ischemia Inhibitor 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide acute reperfusion NLRP3IN2 myocardial NLRP3 Inflammasome Inhibitor I NLRP-3-IN-2 NLRP3 IN 2 inflammasome inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.