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ATP

Catalog No. T20089 CAS 56-65-5

Synonyms: Atipi, ATP disodium salt hydrate, Triphosphoric acid adenosine ester, Ara-ATP, Triphosphaden, Adenosine triphosphate;Ara-ATP, Adenosine triphosphate

ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specific purinergic receptors to mediate a variety of processes including neurotransmission, inflammation, apoptosis, and bone remodeling.

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ATP, CAS 56-65-5

Pack Size	Availability	Price/USD
50 mg	In stock	$ 34.00
100 mg	In stock	$ 48.00
500 mg	In stock	$ 78.00
1 g	In stock	$ 113.00

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Purity: 100%

Purity: 98%

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Description	ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specific purinergic receptors to mediate a variety of processes including neurotransmission, inflammation, apoptosis, and bone remodeling.
In vitro	METHODS: Synovial fibroblast HSF were rapidly treated (wash-in and wash-out ~2 s) with ATP (10 μM) three times, and [Ca2+] changes were detected using Fluo-4 fluorescence. RESULTS: During the first application of ATP, Fluo-4 fluorescence increased rapidly after a delay of a few seconds and decreased slightly before the end of ATP application. After removal of ATP, the fluorescence signal returned to resting levels, but fluorescence decreased much more slowly than it had begun after the initial ATP application. The two subsequent ATP applications produced a response of less amplitude than the first, and the delay until the onset of the response appeared to lengthen with successive applications. [1] METHODS: Mouse bone marrow-derived macrophages BMDM were stimulated with LPS, HKEC, or HKSA, followed by treatment with ATP (2 mM) for 0.5-24 h. Levels of IL-1β, KC, and MIP-2 were determined using ELISA. RESULTS: ATP treatment strongly induced the secretion of IL-1β, KC and MIP-2. [2]
In vivo	METHODS: To test the antibacterial activity in vivo, ATP (50 mg/kg) was injected intraperitoneally into Kunming mice, and E. coli 25922 or S. aureus 25923 was injected 1-24 h later. RESULTS: The administration of ATP 4 h or 24 h before the attack did significantly increase the survival rate of infected mice, regardless of the bacterial type. [2] METHODS: To assay in vivo antibacterial activity, ATP (40 mg/kg), clarithromycin (12 mg/kg), and rifampin (8 mg/kg) were injected subcutaneously into MAC-infected BALB/c mice five times per week for eight weeks. RESULTS: Co-administration of ATP with clarithromycin and rifampin accelerated bacterial clearance in MAC-infected mice without resulting in changes in histopathologic features or mRNA expression of pro- or anti-inflammatory cytokines in mice not given ATP. [3]

Synonyms	Atipi, ATP disodium salt hydrate, Triphosphoric acid adenosine ester, Ara-ATP, Triphosphaden, Adenosine triphosphate;Ara-ATP, Adenosine triphosphate
Molecular Weight	507.18
Formula	C10H16N5O13P3
CAS No.	56-65-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble, Sonication is recommended.

H2O: 100 mg/mL (197.17 mM), Sonication is recommended.

References and Literature

1. Kondo C, et al. ATP triggers a robust intracellular [Ca2+ ]-mediated signalling pathway in human synovial fibroblasts. Exp Physiol. 2018 Aug;103(8):1101-1122. 2. Xiang Y, et al. Adenosine-5'-triphosphate (ATP) protects mice against bacterial infection by activation of the NLRP3 inflammasome. PLoS One. 2013 May 22;8(5):e63759. 3. Tomioka H, et al. Combined effects of ATP on the therapeutic efficacy of antimicrobial drug regimens against Mycobacterium avium complex infection in mice and roles of cytosolic phospholipase A2-dependent mechanisms in the ATP-mediated potentiation of antimycobacterial host resistance. J Immunol. 2005 Nov 15;175(10):6741-9. 4. Zhang R, Li G, Zhang Q, Tang Q, Huang J, Hu C, Liu Y, Wang Q, Liu W, Gao N, Zhou S. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell Death Dis. 2018 May 22;9(6):598. doi: 10.1038/s41419-018-0641-7. PubMed PMID: 29789524.

Related compound libraries

This product is contained In the following compound libraries：

Tobacco Monomer Library Human Endogenous Metabolite Library Drug Repurposing Compound Library Nucleotide Compound Library Human Endogenous Metabolite Compound Library Plus Anti-COVID-19 Traditional Chinese Medicine Compound Library Bioactive Compounds Library Max Mouse Metabolite Compound Library Selected Plant-Sourced Compound Library Human Metabolite Library

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Keywords

ATP 56-65-5 Metabolism Endogenous Metabolite energy Atipi Adenosine Triphosphate inflammation inhibit immunity Inhibitor inflammasome ATP disodium salt hydrate Adenosine 5'-triphosphate ATP disodium Hydrate Triphosphoric acid adenosine ester storage Ara-ATP Adenosine cytokine NLRP3 metabolism Triphosphaden Adenosine triphosphate;Ara-ATP Adenosine triphosphate inhibitor

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