trka — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40294	ITK/TRKA-IN-1
	ITK/TRKA-IN-1 is a chemical compound that functions as a dual inhibitor of IL-2-inducible T-cell kinase (ITK) and tropomyosin receptor kinase A (TRKA). With an IC50 value of 1.0 nM, it effectively inhibits the activity o...
T13208	TrkA-IN-1		Trk receptor
	TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.		Trk receptor
T73306	TrkA-IN-3
	TrkA-IN-3 is a potent, subselective, and allosteric inhibitor of TrkA, demonstrating significant potency with an IC50 of 22.4 nM. It exhibits over 8000-fold selectivity towards TrkA in comparison to TrkB and TrkC, making...
T73307	TrkA-IN-4
	TrkA-IN-4, a potent, orally active and allosteric TrkA inhibitor, is a prodrug of TrkA-IN-3 . TrkA-IN-4 exhibits potent antinociceptive effects [1] .
T62801	FLT3/TrKA-IN-1
	FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor, capable of acting on FLT3 (IC50: 43.8 nM), FLT3-ITD (IC50: 97.2 nM), FLT3-TKD (IC50: 92.5 nM) and TrKA (IC50: 23.6 nM). -FLT3/TrKA-IN-1 has potential for acute ...
T16766	Ro 08-2750
	Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 µM. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM. Ro 08-2...
T12731	RIPK1-IN-7		RIP kinase
	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.		RIP kinase
T9123	DS-1205		TAM Receptor
	DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an...		TAM Receptor
T6712	Tyrphostin AG 879	AG 879	Apoptosis , EGFR , Trk receptor , HER , PDGFR
	Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.		Apoptosis , EGFR , Trk receptor , HER , PDGFR
T0678	Amitriptyline hydrochloride	Amitriptyline HCl,Tryptizol,Domical,Annoyltin	Trk receptor , Sigma receptor , 5-HT Receptor , Serotonin Transporter , Sodium Channel , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
	Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities.
T4349	Sitravatinib	MG516,MGCD516	Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor
	Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl.
T39266	HTrkA-IN-1
	hTrkA-IN-1 is a potent and orally active inhibitor of TrkA kinase with an IC 50 of 1.3 nM, compound 2.hTrkA-IN-1 can be used for the study of inflammatory disease, such as prostatitis, pelvic, et al.
T63223	HTrkA-IN-2
	hTrkA-IN-2 is a selective hTrkA metamorphosis inhibitor (IC50: 3.9 nM).
T7435	Selitrectinib	LOXO-195	Trk receptor
	Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK)( TrkA and TrkC with IC50s of 0.6 and <2.5 nM, respectively)		Trk receptor
T14921	CE-245677		Tie-2 , Trk receptor
	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.		Tie-2 , Trk receptor
T6052	GW 441756		Apoptosis , Raf , Trk receptor , CDK
	GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.		Apoptosis , Raf , Trk receptor , CDK
T6097	GNF-5837	GNF 5837	Trk receptor , PDGFR , c-Kit
	GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).		Trk receptor , PDGFR , c-Kit
T14363	AZ-23	AZ 23,AZ23	Trk receptor
	AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.		Trk receptor
T5635	CH7057288		Trk receptor
	CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.		Trk receptor
T4257	Belizatinib	TSR-011	Trk receptor , ALK
	Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.		Trk receptor , ALK