Search Result

Search Results for " tie2 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T6335	Tie2 kinase inhibitor 1	Tie2 kinase inhibitor	Tie-2
	Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor), an optimized compound of SB-203580, is selective to Tie2 with IC50 of 0.25 μM, which is 200-fold more effective than p38.		Tie-2
T22259	AMG-Tie2-1	AMG-Tie2	Others
	AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2).		Others
T36718	Tie2 Inhibitor 7
	Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound c...
T8817	TIE-2/VEGFR-2 kinase-IN-1
	TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors that can be used for the study of diseases associated with inappropriate angiogenesis [1].
T40581	TIE-2/VEGFR-2 kinase-IN-2
	TIE-2/VEGFR-2 kinase-IN-2 is a powerful inhibitor of both VEGFR2 and Tie-2 kinases, displaying noteworthy pIC 50 values of 8.61 and 8.56, respectively. This compound acts as an anti-angiogenic agent, making it highly rel...
T14921	CE-245677		Tie-2 , Trk receptor
	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.		Tie-2 , Trk receptor
T6154	SU11274	Met Kinase Inhibitor,PKI-SU11274	Apoptosis , VEGFR , FGFR , c-Met/HGFR , CDK , Autophagy
	SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.		Apoptosis , VEGFR , FGFR , c-Met/HGFR , CDK , Autophagy
T16724	Razuprotafib	AKB-9778	Phosphatase , Others
	Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor (IC50: 50 nM). Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury.		Phosphatase , Others
T2640	Rebastinib	DCC2036,DCC 2036,DCC-2036	Apoptosis , FLT , Bcr-Abl , Src
	DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Re...		Apoptosis , FLT , Bcr-Abl , Src
T6380	AMG 900	AMG900,AMG-900	p38 MAPK , Tyrosine Kinases , Aurora Kinase
	AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.		p38 MAPK , Tyrosine Kinases , Aurora Kinase
T6289	Dovitinib	TKI258,CHIR-258	VEGFR , FGFR , FLT , PDGFR , c-Kit
	Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to E...		VEGFR , FGFR , FLT , PDGFR , c-Kit
T6479	Dovitinib lactate hydrate	Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258	VEGFR , FGFR , FLT , PDGFR , c-Kit
	Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) R...		VEGFR , FGFR , FLT , PDGFR , c-Kit
T2054	Altiratinib	DCC-2701	VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
	Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist...		VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
T79860	TIE-2/VEGFR-2 kinase-IN-5		VEGFR , Tie-2
	TIE-2/VEGFR-2 kinase-IN-5 is a potent TIE-2 and VEGFR-2 tyrosine kinase receptor inhibitor with anti-angiogenic activity and is commonly used in biomedical research related to angiogenesis.		VEGFR , Tie-2
T6934	Pexmetinib	ARRY-614	Tie-2 , p38 MAPK , Autophagy
	Pexmetinib (ARRY-614) (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.		Tie-2 , p38 MAPK , Autophagy
T16853	SB-633825		BTK
	SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 150 nM, respectively).		BTK
T4318	EOC317	ACTB-1003,ACTB1003,ACTB 1003	VEGFR , FGFR , Tie-2
	EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).		VEGFR , FGFR , Tie-2
T68539	CEP-11981	BOL 303213X,ESK981 ; BOL 303213X,ESK981
	CEP-11981 (ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI) that targets TIE2, VEGFR1-3, and FGFR1. It exhibits potential anti-tumor and anti-angiogenic effects.
T68286	CE-245677 mesylate
	CE-245677 is a selective, orally active Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases w...
T78248	Nesvacumab
	Nesvacumab, a fully human immunoglobulin G1 (IgG1) monoclonal antibody, selectively binds to and inactivates Angiopoietin-2 (Ang2), the ligand for the Tie2 receptor, with high affinity, while exhibiting no affinity for A...
T6193	Dovitinib Dilactic Acid	Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic acid	VEGFR , FGFR , FLT , c-Kit
	Dovitinib Dilactic Acid (Dovitinib (TKI-258) Dilactic Acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FG...		VEGFR , FGFR , FLT , c-Kit
T3113	Foretinib	GSK089,EXEL-2880,GSK1363089,XL880	VEGFR , Tie-2 , c-Met/HGFR
	Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.		VEGFR , Tie-2 , c-Met/HGFR
T38930	BAY-826		Tie-2
	BAY-826 is a novel, potent and selective TIE-2 inhibitor that inhibits TIE-2 phosphorylation and can be used to study tumors.		Tie-2
T79859	TIE-2/VEGFR-2 kinase-IN-4
	TIE-2/VEGFR-2 kinase-IN-4, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting inhibitory concentration (IC50) values of 5.2 nM and 5.1 nM, respectively...
T79858	TIE-2/VEGFR-2 kinase-IN-3
	TIE-2/VEGFR-2 kinase-IN-3, a benzimidazole derivative, serves as a potent inhibitor of the tyrosine kinase receptors TIE-2 and VEGFR-2, exhibiting IC50 values of 6.9 nM and 3.5 nM, respectively. This compound is useful f...

Compounds

Tie2 kinase inhibitor 1

T6335

Synonym: Tie2 kinase inhibitor

TIE-2/VEGFR-2 kinase-IN-1

T8817

Synonym:

Target:

TIE-2/VEGFR-2 kinase-IN-2

Target: Tie-2, Trk receptor

SU11274

T6154

Synonym: Met Kinase Inhibitor,PKI-SU11274

Target: Apoptosis, VEGFR, FGFR, c-Met/HGFR, CDK, Autophagy

Razuprotafib

T16724

Synonym: AKB-9778

Target: Phosphatase, Others

Rebastinib

T2640

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

AMG 900

T6380

Synonym: AMG900,AMG-900

Target: p38 MAPK, Tyrosine Kinases, Aurora Kinase

Dovitinib

T6289

Synonym: TKI258,CHIR-258

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Dovitinib lactate hydrate

T6479

Synonym: Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258

Target: VEGFR, FGFR, FLT, PDGFR, c-Kit

Altiratinib

T2054

Synonym: DCC-2701

Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR

TIE-2/VEGFR-2 kinase-IN-5

T79860

Synonym:

Target: VEGFR, Tie-2

Pexmetinib

T6934

Synonym: ARRY-614

Target: Tie-2, p38 MAPK, Autophagy

Synonym: ACTB-1003,ACTB1003,ACTB 1003

Target: VEGFR, FGFR, Tie-2

CEP-11981

T68539

Synonym: BOL 303213X,ESK981 ; BOL 303213X,ESK981

Dovitinib Dilactic Acid

T6193

Synonym: Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic acid

Target: VEGFR, FGFR, FLT, c-Kit

Foretinib

T3113

Synonym: GSK089,EXEL-2880,GSK1363089,XL880

Target: VEGFR, Tie-2, c-Met/HGFR

TIE-2/VEGFR-2 kinase-IN-4

T79859

Synonym:

Target:

TIE-2/VEGFR-2 kinase-IN-3

T79858

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01064	TIE2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
TMPY-00930	TIE2 Protein, Human, Recombinant (His & hFc)	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1.
TMPJ-00642	TIE2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1.
TMPY-05244	TIE2 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
TMPY-04545	TIE2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	TIE2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.3 kDa and the accession number is Q02763-1.
TMPY-01954	TIE2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	TIE2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.7 kDa and the accession number is B1AWS8.
TMPY-06974	TIE2 Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293 Cells
	TIE2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.03 kDa and the accession number is Q02858.
TMPJ-00643	TIE2 Protein, Human, Recombinant (aa 23-745, His)	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (aa 23-745, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-120 KDa and the accession number is Q02763-1.
TMPY-04575	TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST)	Mouse	Baculovirus Insect Cells
	TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.2kDa and the accession number is Q02858.
TMPY-05049	TIE2 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293 Cells
	TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9.
TMPY-02508	TIE2 Protein, Rat, Recombinant (hFc)	Rat	HEK293 Cells
	TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8.
TMPY-03563	TIE2 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293 Cells
	TIE2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.6 kDa and the accession number is G7PS68.
TMPK-00303	ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Angiopoietin-2 (Ang-2; also ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Mature Ang-2 is 478 amino acids in length.Ang2 is widely expressed during development, but it is ...
TMPJ-00303	ANG2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	ANG2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is O35608.
TMPJ-01435	ANG2 Protein, Rhesus macaque, Recombinant (hFc)	Rhesus	HEK293 Cells
	ANG2 Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is XM_001097949.
TMPH-03240	Angiopoietin-2 Protein, Rat, Recombinant (His)	Rat	Baculovirus Insect Cells
	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, AN...
TMPH-03241	Angiopoietin-2 Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, AN...
TMPH-00479	Angiopoietin-1 Protein, Canine, Recombinant (His)	Canine	Baculovirus Insect Cells
	Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal i...
TMPH-00343	Angiopoietin-1 Protein, Canine, Recombinant (HEK293, His)	Canine	HEK293 Cells
	Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal i...
TMPH-03239	Angiopoietin-1 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal i...