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Razuprotafib

Name: Razuprotafib
Brand: TargetMol
SKU: T16724
Price: 253 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16724Cas No. 1008510-37-9

Alias AKB-9778

Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.

Razuprotafib

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Purity: 99.76%

Catalog No. T16724Alias AKB-9778Cas No. 1008510-37-9

Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$253	In Stock	In Stock
5 mg	$413	In Stock	In Stock
10 mg	$619	In Stock	In Stock
25 mg	$1,050	In Stock	In Stock
50 mg	$1,370	In Stock	In Stock
100 mg	$1,790	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$533	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.76%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor with an IC50 of 50 nM. It effectively activates Tie-2 and provides protection against acute kidney injury.
Targets&IC50	HPTPß:50 nM
In vitro	Razuprotafib inhibits the phosphatase activity of VE-PTP with an IC50 of 17 pM. Razuprotafib inhibits the phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib inhibits HPTPη (IC50 = 36 pM) . Razuprotafib inhibits HPTPγ (IC50 = 100 pM). Razuprotafib 0.17 to 50 μM HUVEC 10 minutes in WB concentration-dependent phosphorylation of TIE2 and downstream components of the TIE2 signaling pathway, including eNOS, AKT, and ERK.
In vivo	Rho-VEGF–transgenic mice s.c. injection 20 mg/kg 12 hours promotes phosphorylation of TIE2 in retinal endothelial cells Rho-VEGF mice s.c. injection 10-20 mg/kg twice daily for 7 days suppresses subretinal neovascularization.
Synonyms	AKB-9778

Chemical Properties

Molecular Weight	586.7
Formula	C₂₆H₂₆N₄O₆S₃
Cas No.	1008510-37-9
Smiles	COC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(NS(O)(=O)=O)cc1)c1csc(n1)-c1cccs1
Relative Density.	1.450 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (255.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7044 mL	8.5222 mL	17.0445 mL	85.2224 mL
5 mM	0.3409 mL	1.7044 mL	3.4089 mL	17.0445 mL
10 mM	0.1704 mL	0.8522 mL	1.7044 mL	8.5222 mL
20 mM	0.0852 mL	0.4261 mL	0.8522 mL	4.2611 mL
50 mM	0.0341 mL	0.1704 mL	0.3409 mL	1.7044 mL
100 mM	0.0170 mL	0.0852 mL	0.1704 mL	0.8522 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc