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Altiratinib

Catalog No. T2054 CAS 1345847-93-9

Synonyms: DCC-2701

Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist in vitro.

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Altiratinib, CAS 1345847-93-9

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Purity: 98%

Biological Description

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Description	Altiratinib(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with an HGF antagonist in vitro.
Targets&IC50	TrkC:0.85 nM, TrkA:0.85 nM, MET Y1230C:0.37 nM, MET Y1230C:1.2 nM, MET D1228N:1.3 nM

Synonyms	DCC-2701
Molecular Weight	510.473
Formula	C26H21F3N4O4
CAS No.	1345847-93-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kwon Y, et al. Oncogene. 2015 Jan 8;34(2):144-53.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Preclinical Compound Library Anti-Lung Cancer Compound Library Cytokine Inhibitor Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Fluorochemical Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

Macrocarpal B SYN1143 N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenylpropanohydrazide AMG-458 Unecritinib S49076 HCl Glesatinib Glesatinib hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Altiratinib 1345847-93-9 蛋白酪氨酸激酶血管生成 c-Met/HGFR FLT Tie-2 Trk receptor VEGFR Cluster of differentiation antigen 135 DCC 2701 Trk Receptor Inhibitor CD135 inhibit FLT3 Vascular endothelial growth factor receptor Tropomyosin related kinase receptor DCC-2701 DCC2701 Fms like tyrosine kinase 3 inhibitor

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